Iopamidol

Iopamidol Brand Names

Isovue | Isovue-M 200 | Isovue-M 300

What is Iopamidol

Iopamidol is an iodinated nonionic, low-osmolar contrast medium used for visualization during angiography and excretory urography.

In addition, an intrathecal formulation is available for use during myelography and to enhance myelographic computed tomography imaging (cisternography and ventriculography).

Iopamidol is used to enhance computed tomography head and body imaging and to investigate the presence of cerebral infarctions, active infections, arteriovenous malformations, aneurysms and lesions or tumors (both malignant and nonneoplastic) in the liver, kidneys, pancreas, aorta, abdominal cavity, pelvis, retroperitoneal space, and the mediastinum.

Iopamidol was approved by the FDA on December 31, 1985.

Indications

  1. angiography
  2. computed tomography (CT) imaging
  3. myelography
  4. urography

Side Effects

  1. acute generalized exanthematous pustulosis (AGEP)
  2. agitation
  3. amnesia
  4. anaphylactic shock
  5. anaphylactoid reactions
  6. angina
  7. angioedema
  8. anorexia
  9. anuria
  10. anxiety
  11. aphasia
  12. apnea
  13. arachnoiditis
  14. aseptic meningitis
  15. asterixis
  16. ataxia
  17. back pain
  18. bleeding
  19. bradycardia
  20. bronchospasm
  21. cardiac arrest
  22. chest pain (unspecified)
  23. chills
  24. coma
  25. confusion
  26. conjunctivitis
  27. cough
  28. cyanosis
  29. depression
  30. diaphoresis
  31. diarrhea
  32. disseminated intravascular coagulation (DIC)
  33. dizziness
  34. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
  35. dysgeusia
  36. dyspepsia
  37. dyspnea
  38. ecchymosis
  39. erythema
  40. fatigue
  41. fever
  42. flushing
  43. Guillain-Barre syndrome
  44. hallucinations
  45. headache
  46. hematoma
  47. hematuria
  48. hot flashes
  49. hyperesthesia
  50. hyperhidrosis
  51. hypertension
  52. hypertensive crisis
  53. hyperthermia
  54. hyperthyroidism
  55. hypertonia
  56. hypotension
  57. hypothyroidism
  58. hypoxia
  59. injection site reaction
  60. involuntary movements
  61. irritability
  62. laryngeal edema
  63. laryngospasm
  64. maculopapular rash
  65. malaise
  66. meningitis
  67. muscle cramps
  68. musculoskeletal pain
  69. myelitis
  70. myocardial infarction
  71. myoclonia
  72. nasal congestion
  73. nausea
  74. neutropenia
  75. oliguria
  76. pallor
  77. paresis
  78. paresthesias
  79. peripheral edema
  80. peripheral neuropathy
  81. peripheral vasodilation
  82. petechiae
  83. polyuria
  84. pruritus
  85. pulmonary edema
  86. rash
  87. renal failure (unspecified)
  88. renal tubular necrosis
  89. restlessness
  90. retroperitoneal bleeding
  91. rhabdomyolysis
  92. rhinitis
  93. seizures
  94. sinus tachycardia
  95. skin discoloration
  96. skin necrosis
  97. sneezing
  98. Stevens-Johnson syndrome
  99. stroke
  100. syncope
  101. thromboembolism
  102. thrombosis
  103. thyrotoxicosis
  104. tissue necrosis
  105. toxic epidermal necrolysis
  106. tremor
  107. urinary retention
  108. urticaria
  109. ventricular fibrillation
  110. vertigo
  111. visual impairment
  112. vomiting
  113. weakness
  114. wheezing
  115. xerostomia

Monitoring Parameters

  • serum creatinine/BUN

Contraindications

  • alcoholism
  • arteriosclerosis
  • asthma
  • atopy
  • breast-feeding
  • cardiac disease
  • children
  • coagulopathy
  • corticosteroid therapy
  • dehydration
  • diabetes mellitus
  • emphysema
  • extravasation
  • females
  • geriatric
  • heart failure
  • hepatic disease
  • hyperthyroidism
  • hypothyroidism
  • increased intracranial pressure
  • infants
  • infection
  • intracranial mass
  • intrathecal administration
  • iodine hypersensitivity
  • multiple myeloma
  • multiple sclerosis
  • myasthenia gravis
  • neonates
  • pheochromocytoma
  • pregnancy
  • premature neonates
  • pulmonary disease
  • pulmonary hypertension
  • QT prolongation
  • radiopaque contrast media hypersensitivity
  • renal disease
  • renal failure
  • renal impairment
  • seizure disorder
  • seizures
  • serious rash
  • sickle cell disease
  • thromboembolic disease
  • thyroid disease
  • thyrotoxicosis
  • valvular heart disease

Interactions

  • Acebutolol
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Tramadol
  • Acyclovir
  • Aldesleukin, IL-2
  • Alogliptin; Metformin
  • Aminoglycosides
  • Amiodarone
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amoxapine
  • Amphetamine
  • Amphetamine; Dextroamphetamine
  • Amphetamine; Dextroamphetamine Salts
  • Amphotericin B
  • Angiotensin-converting enzyme inhibitors
  • Aprotinin
  • Aripiprazole
  • Asenapine
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Atenolol
  • Atenolol; Chlorthalidone
  • Bendroflumethiazide; Nadolol
  • Benzphetamine
  • Beta-blockers
  • Betamethasone
  • Betaxolol
  • Bictegravir; Emtricitabine; Tenofovir Alafenamide
  • Bisoprolol
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Brexpiprazole
  • Brimonidine; Timolol
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Dextromethorphan; Phenylephrine
  • Bumetanide
  • Bupropion
  • Bupropion; Naltrexone
  • Caffeine
  • Caffeine; Ergotamine
  • Canagliflozin; Metformin
  • Capreomycin
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Phenylephrine
  • Carteolol
  • Carvedilol
  • Chlophedianol; Guaifenesin; Phenylephrine
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Phenylephrine
  • Cisplatin
  • Clomipramine
  • Clonazepam
  • Clozapine
  • Cocaine
  • Codeine; Phenylephrine; Promethazine
  • Colistimethate, Colistin, Polymyxin E
  • Cyclobenzaprine
  • Cyclosporine
  • Dapagliflozin; Metformin
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Deferasirox
  • Desipramine
  • Dexamethasone
  • Dexmethylphenidate
  • Dextroamphetamine
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Diethylpropion
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Phenylephrine
  • Dopamine
  • Doravirine; Lamivudine; Tenofovir disoproxil fumarate
  • Dorzolamide; Timolol
  • Doxepin
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Emtricitabine; Tenofovir alafenamide
  • Emtricitabine; Tenofovir disoproxil fumarate
  • Entecavir
  • Ephedrine
  • Ertugliflozin; Metformin
  • Esmolol
  • Ethacrynic Acid
  • Ethanol
  • Fluoxetine; Olanzapine
  • Furosemide
  • Glipizide; Metformin
  • Glyburide; Metformin
  • Green Tea
  • Guaifenesin; Phenylephrine
  • Haloperidol
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrocodone; Phenylephrine
  • Hydrocortisone
  • Ibandronate
  • Iloperidone
  • Imipramine
  • Labetalol
  • Lamivudine; Tenofovir Disoproxil Fumarate
  • Levobetaxolol
  • Levobunolol
  • Linagliptin; Metformin
  • Lisdexamfetamine
  • Loop diuretics
  • Lorazepam
  • Loxapine
  • Lurasidone
  • Maprotiline
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methamphetamine
  • Methylphenidate
  • Methylprednisolone
  • Metoprolol
  • Midodrine
  • Molindone
  • Monoamine oxidase inhibitors
  • Nadolol
  • Nebivolol
  • Nebivolol; Valsartan
  • Nonsteroidal antiinflammatory drugs
  • Norepinephrine
  • Nortriptyline
  • Olanzapine
  • Oxaliplatin
  • Pamidronate
  • Pemoline
  • Penbutolol
  • Perphenazine; Amitriptyline
  • Phendimetrazine
  • Phenothiazines
  • Phentermine
  • Phentermine; Topiramate
  • Phenylephrine
  • Phenylephrine; Promethazine
  • Pimozide
  • Pindolol
  • Polymyxins
  • Prednisolone
  • Propranolol
  • Protriptyline
  • Quetiapine
  • Risperidone
  • Sodium Iodide
  • Sodium Oxybate
  • Sotalol
  • Telbivudine
  • Tenofovir Alafenamide
  • Tenofovir Alafenamide
  • Tenofovir, PMPA
  • Theophylline, Aminophylline
  • Thiothixene
  • Thyroid hormones
  • Timolol
  • Torsemide
  • Tramadol
  • Tricyclic antidepressants
  • Trimipramine
  • Valacyclovir
  • Ziprasidone
  • Zoledronic Acid
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