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Interferon Beta 1b Brand Names- Betaseron | Extavia
What is Interferon Beta 1b
Interferon beta 1b is available through recombinant DNA technology.
Interferon beta-1b has been shown to decrease both the number and severity of multiple sclerosis (MS) attacks (i.e., relapses) and to significantly slow the progression of physical disability associated with relapsing-remitting MS, such as clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease in adults.
Early treatment of MS with proper therapy may delay cognitive and physical disability.
The interferon beta medications are generally considered the initial treatment options for pediatric patients with MS.
Interferon beta 1b has also been studied in the treatment of many other conditions.
The FDA initially approved interferon beta 1b in 1993.
Indications
- multiple sclerosis
For treatment of relapsing forms of multiple sclerosis (MS), including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease
Side Effects
- abdominal pain
- alopecia
- anaphylactic shock
- anaphylactoid reactions
- anemia
- angioedema
- anorexia
- antibody formation
- anxiety
- arthralgia
- asthenia
- bronchospasm
- capillary leak syndrome
- cardiomyopathy
- chest pain (unspecified)
- chills
- confusion
- constipation
- depression
- diaphoresis
- diarrhea
- dizziness
- dysmenorrhea
- dyspepsia
- dyspnea
- elevated hepatic enzymes
- emotional lability
- erythema
- fever
- headache
- heart failure
- hemolytic-uremic syndrome
- hepatic failure
- hepatitis
- hypertension
- hyperthyroidism
- hypertonia
- hypertriglyceridemia
- hypothyroidism
- impotence (erectile dysfunction)
- infection
- injection site reaction
- insomnia
- leukopenia
- lupus-like symptoms
- lymphadenopathy
- lymphopenia
- malaise
- menorrhagia
- menstrual irregularity
- muscle cramps
- myalgia
- myasthenia
- nausea
- neutropenia
- palpitations
- pancreatitis
- peripheral edema
- peripheral vasodilation
- pruritus
- rash
- seizures
- sinus tachycardia
- spontaneous fetal abortion
- suicidal ideation
- thrombocytopenia
- thrombotic microangiopathy
- thrombotic thrombocytopenic purpura (TTP)
- tissue necrosis
- urinary urgency
- urticaria
- vasculitis
- vomiting
- weight gain
- weight loss
Monitoring Parameters
- CBC
- LFTs
- platelet count
Contraindications
- albumin hypersensitivity
- bone marrow suppression
- breast-feeding
- children
- depression
- E. coli protein hypersensitivity
- heart failure
- hemolytic-uremic syndrome
- hepatic disease
- hepatitis
- hyperthyroidism
- hypothyroidism
- infants
- latex hypersensitivity
- mannitol hypersensitivity
- neonates
- pregnancy
- seizures
- suicidal ideation
- thrombotic thrombocytopenic purpura (TTP)
- thyroid disease
Interactions
- Abacavir
- Abacavir; Dolutegravir; Lamivudine
- Abacavir; Lamivudine, 3TC
- Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
- Amprenavir
- Atazanavir
- Atazanavir; Cobicistat
- Bictegravir; Emtricitabine; Tenofovir Alafenamide
- Chloroquine
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Dolutegravir; Lamivudine
- Dolutegravir; Rilpivirine
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Emtricitabine
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Emtricitabine; Tenofovir alafenamide
- Emtricitabine; Tenofovir disoproxil fumarate
- Entecavir
- Ethanol
- Fosamprenavir
- Indinavir
- Lamivudine, 3TC
- Lamivudine, 3TC; Zidovudine, ZDV
- Lamivudine; Tenofovir Disoproxil Fumarate
- Lopinavir; Ritonavir
- Natalizumab
- Nelfinavir
- Nevirapine
- Ocrelizumab
- Ombitasvir; Paritaprevir; Ritonavir
- Ozanimod
- Pexidartinib
- Protease inhibitors
- Rilpivirine
- Riluzole
- Ritonavir
- Saquinavir
- Stavudine, d4T
- Telbivudine
- Tipranavir
- Vigabatrin
- Zalcitabine, ddC
- Zidovudine, ZDV
