Interferon Alfa n3

Interferon Alfa n3 Brand Name– Alferon N

What is Interferon Alfa n3

Interferon alfa n3 is a formulation of purified, natural, human interferon (IFN) alpha proteins derived from human leukocytes.

Alpha and beta IFNs are structurally and functionally related.

The alpha IFNs include more than 25 subtypes; interferon alfa-3n consists of IFN alpha proteins comprising approximately 166 amino acids in molecular weights from 16—27 Kd. The specific activity of interferon alfa-n3 is >= 200 million International Units/mg protein.

Interferon alfa-n3 is manufactured from pooled units of human leukocytes that have been induced by incomplete infection with a murine virus (Sendai virus) to produce interferon alfa-n3.

The manufacturing process includes immunoaffinity chromotography with a murine antibody and gel filtration chromotography. In addition, the manufacturing process contains steps that have been shown to inactivate viruses, and there has been no evidence of infection transmission during clinical trials.

Interferon alfa n3 is used in the treatment of condylomata acuminata (venereal or genital warts).

Overall, 80% of patients treated with interferon alfa-n3 had a complete or partial resolution of genital warts compared to only 44% of those treated with placebo.

Interferon alfa-n3 has also been used to treat chronic myelogenous leukemia and hepatitis C in patients who have developed antibodies to or are refractory to other interferon alfa products.

The FDA approved interferon alfa-n3 for the treatment of venereal warts in 1990.

Indications

  1. adenovirus
  2. condylomata acuminata
  3. encephalomyocarditis virus
  4. hepatitis B virus
  5. hepatitis C virus
  6. hepatitis D virus
  7. herpes simplex virus type 1
  8. herpes simplex virus type 2
  9. human immunodeficiency virus (HIV)
  10. human papillomavirus (HPV)
  11. human papillomavirus (HPV) infection
  12. human T-lymphotropic virus type I (HTLV-I)
  13. poliovirus
  14. rhinovirus
  15. varicella-zoster virus
  16. variola virus (smallpox)
  17. vesicular stomatitis virus

Side Effects

  1. anorexia
  2. arthralgia
  3. back pain
  4. bleeding
  5. blurred vision
  6. chest pain (unspecified)
  7. chills
  8. confusion
  9. constipation
  10. cough
  11. depression
  12. diaphoresis
  13. diarrhea
  14. dizziness
  15. drowsiness
  16. dysgeusia
  17. dyspepsia
  18. dysuria
  19. edema
  20. epistaxis
  21. fatigue
  22. fever
  23. flushing
  24. headache
  25. heat intolerance
  26. hot flashes
  27. hyperesthesia
  28. hypersalivation
  29. hypotension
  30. injection site reaction
  31. insomnia
  32. leukopenia
  33. maculopapular rash
  34. malaise
  35. muscle cramps
  36. myalgia
  37. nausea
  38. non-arteritic anterior ischemic optic neuropathy
  39. ocular pain
  40. paresthesias
  41. pharyngitis
  42. photosensitivity
  43. polydipsia
  44. pruritus
  45. pyrosis (heartburn)
  46. stomatitis
  47. tinnitus
  48. visual impairment
  49. vomiting
  50. wheezing
  51. xerostomia

Monitoring Parameters

  • CBC
  • LFTs

Contraindications

  • albumin hypersensitivity
  • angina
  • bone marrow suppression
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • children
  • chronic obstructive pulmonary disease (COPD)
  • coronary artery disease
  • diabetes mellitus
  • egg hypersensitivity
  • geriatric
  • Graves’ disease
  • heart failure
  • hemophilia
  • hyperlipidemia
  • hypertension
  • hyperthyroidism
  • hypothyroidism
  • infants
  • infection
  • murine protein hypersensitivity
  • neomycin hypersensitivity
  • neonates
  • non-arteritic anterior ischemic optic neuropathy
  • pregnancy
  • psoriasis
  • pulmonary disease
  • seizure disorder
  • thyroid disease
  • vaccination
  • viral infection

Interactions

  • Abacavir
  • Abacavir; Dolutegravir; Lamivudine
  • Abacavir; Lamivudine, 3TC
  • Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
  • Aldesleukin, IL-2
  • Alemtuzumab
  • Alteplase
  • Altretamine
  • Amprenavir
  • Anticoagulants
  • Antithrombin III
  • Antithymocyte Globulin
  • Antitumor antibiotics
  • Apixaban
  • Argatroban
  • Arsenic Trioxide
  • Atazanavir
  • Atazanavir; Cobicistat
  • Azathioprine
  • Bacillus Calmette-Guerin Vaccine, BCG
  • Basiliximab
  • Betrixaban
  • Bictegravir; Emtricitabine; Tenofovir Alafenamide
  • Bivalirudin
  • Chloroquine
  • Clozapine
  • Dabigatran
  • Dalteparin
  • Danaparoid
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Delavirdine
  • Desirudin
  • Dolutegravir; Lamivudine
  • Dolutegravir; Rilpivirine
  • Doravirine; Lamivudine; Tenofovir disoproxil fumarate
  • Edoxaban
  • Efalizumab
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Emtricitabine
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Emtricitabine; Tenofovir alafenamide
  • Emtricitabine; Tenofovir disoproxil fumarate
  • Enoxaparin
  • Entecavir
  • Estramustine
  • Ethanol
  • Filgrastim, G-CSF
  • Folate analogs
  • Fondaparinux
  • Fosamprenavir
  • Heparin
  • Hydroxyurea
  • Ibritumomab Tiuxetan
  • Imatinib
  • Indinavir
  • Influenza Virus Vaccine
  • Intranasal Influenza Vaccine
  • Lamivudine, 3TC
  • Lamivudine, 3TC; Zidovudine, ZDV
  • Lamivudine; Tenofovir Disoproxil Fumarate
  • Lepirudin
  • Live Vaccines
  • Lomustine, CCNU
  • Lopinavir; Ritonavir
  • Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
  • Measles/Mumps/Rubella Vaccines, MMR
  • Melphalan
  • Methotrexate
  • Methoxsalen
  • Mitoxantrone
  • Natural Antineoplastics
  • Nelfinavir
  • Nevirapine
  • Ombitasvir; Paritaprevir; Ritonavir
  • Pegfilgrastim
  • Pemetrexed
  • Pentosan
  • Pexidartinib
  • Pralatrexate
  • Protease inhibitors
  • Purine analogs
  • Reteplase, r-PA
  • Rilpivirine
  • Riluzole
  • Ritonavir
  • Rivaroxaban
  • Rotavirus Vaccine
  • Rubella Virus Vaccine Live
  • Saquinavir
  • Smallpox and Monkeypox Vaccine, Live, Nonreplicating
  • Smallpox Vaccine, Vaccinia Vaccine
  • Stavudine, d4T
  • Streptokinase
  • Tbo-Filgrastim
  • Telbivudine
  • Tenecteplase
  • Theophylline, Aminophylline
  • Thrombolytic Agents
  • Tinzaparin
  • Tipranavir
  • Tositumomab
  • Tretinoin, ATRA
  • Typhoid Vaccine
  • Urokinase
  • Varicella-Zoster Virus Vaccine, Live
  • Vigabatrin
  • Warfarin
  • Yellow Fever Vaccine, Live
  • Zalcitabine, ddC
  • Zidovudine, ZDV
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