Inotuzumab Ozogamicin Brand Name– BESPONSA
What is Inotuzumab Ozogamicin
Inotuzumab ozogamicin is a CD22-directed antibody-drug conjugate approved for the treatment of adults with relapsed or refractory B-cell precursor acute lymphoblastic leukemia.
Severe or life-threatening hepatotoxicity including veno-occlusive disease/sinusoidal obstruction syndrome has been reported.
Patients who undergo a hematopoietic stem-cell transplant following inotuzumab ozogamicin therapy may have a higher risk for nonrelapse mortality
Indications
- acute lymphocytic leukemia (ALL)
For the treatment of acute lymphocytic leukemia (ALL)
NOTE: Inotuzumab ozogamicin has been designated an orphan drug by the FDA for the treatment of B-cell ALL.
Side Effects
- abdominal pain
- abdominal pain
- anemia
- anemia
- anorexia
- anorexia
- antibody formation
- ascites
- asthenia
- asthenia
- bleeding
- bleeding
- chills
- constipation
- diarrhea
- diarrhea
- ecchymosis
- ecchymosis
- elevated hepatic enzymes
- elevated hepatic enzymes
- epistaxis
- fatigue
- fatigue
- fever
- fever
- GI bleeding
- headache
- headache
- hematemesis
- hematoma
- hematoma
- hematuria
- hematuria
- hemorrhoids
- hemorrhoids
- hepatomegaly
- hepatotoxicity
- hyperamylasemia
- hyperbilirubinemia
- hyperbilirubinemia
- hyperuricemia
- infection
- infection
- infusion-related reactions
- intracranial bleeding
- leukopenia
- leukopenia
- lymphopenia
- lymphopenia
- migraine
- migraine
- nausea
- nausea
- neutropenia
- neutropenia
- oral ulceration
- oral ulceration
- pancytopenia
- petechiae
- petechiae
- QT prolongation
- rash
- sinusoidal obstruction syndrome (SOS)
- stomatitis
- stomatitis
- subdural hematoma
- subdural hematoma
- thrombocytopenia
- thrombocytopenia
- tumor lysis syndrome (TLS)
- vaginal bleeding
- vaginal bleeding
- veno-occlusive disease (VOD)
- vomiting
- vomiting
- weight gain
Monitoring Parameters
- CBC with differential
- ECG
- LFTs
- pregnancy testing
- serum bilirubin
- serum electrolytes
- weight
Contraindications
- apheresis
- AV block
- bleeding
- bone marrow suppression
- bradycardia
- breast-feeding
- cardiomyopathy
- celiac disease
- contraception requirements
- electrolyte imbalance
- females
- fever
- geriatric
- heart failure
- hepatic disease
- hepatotoxicity
- human immunodeficiency virus (HIV) infection
- hyperparathyroidism
- hypocalcemia
- hypokalemia
- hypomagnesemia
- hypothermia
- hypothyroidism
- infection
- infertility
- infusion-related reactions
- long QT syndrome
- male-mediated teratogenicity
- mortality
- myocardial infarction
- neutropenia
- pheochromocytoma
- pregnancy
- pregnancy testing
- QT prolongation
- reproductive risk
- rheumatoid arthritis
- sickle cell disease
- sinusoidal obstruction syndrome (SOS)
- sleep deprivation
- stroke
- systemic lupus erythematosus (SLE)
- thrombocytopenia
- veno-occlusive disease (VOD)
Interactions
- Aclidinium; Formoterol
- Albuterol
- Albuterol; Ipratropium
- Alfuzosin
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Anagrelide
- Apomorphine
- Arformoterol
- Aripiprazole
- Arsenic Trioxide
- Artemether; Lumefantrine
- Asenapine
- Atomoxetine
- Azithromycin
- Bedaquiline
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Budesonide; Formoterol
- Buprenorphine
- Buprenorphine; Naloxone
- Ceritinib
- Chloroquine
- Chlorpromazine
- Ciprofloxacin
- Cisapride
- Citalopram
- Clarithromycin
- Clofazimine
- Clomipramine
- Clozapine
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Crizotinib
- Dasatinib
- Degarelix
- Desflurane
- Desipramine
- Deutetrabenazine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Disopyramide
- Dofetilide
- Dolasetron
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Doxepin
- Dronedarone
- Droperidol
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Eliglustat
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Encorafenib
- Enflurane
- Entrectinib
- Eribulin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Ezogabine
- Fingolimod
- Flecainide
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvoxamine
- Formoterol
- Formoterol; Mometasone
- Foscarnet
- Gemifloxacin
- Gilteritinib
- Glasdegib
- Glycopyrrolate; Formoterol
- Goserelin
- Granisetron
- Halogenated Anesthetics
- Haloperidol
- Halothane
- Histrelin
- Hydroxychloroquine
- Hydroxyzine
- Ibutilide
- Iloperidone
- Imipramine
- Indacaterol
- Indacaterol; Glycopyrrolate
- Isoflurane
- Itraconazole
- Ivosidenib
- Ketoconazole
- Lapatinib
- Lefamulin
- Lenvatinib
- Leuprolide
- Leuprolide; Norethindrone
- Levalbuterol
- Levofloxacin
- Lithium
- Lofexidine
- Long-acting beta-agonists
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Macimorelin
- Maprotiline
- Mefloquine
- Meperidine; Promethazine
- Metaproterenol
- Methadone
- Metronidazole
- Midostaurin
- Mifepristone
- Mirtazapine
- Moxifloxacin
- Nilotinib
- Nortriptyline
- Octreotide
- Ofloxacin
- Olanzapine
- Olodaterol
- Ondansetron
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Ozanimod
- Palifermin
- Paliperidone
- Panobinostat
- Pasireotide
- Pazopanib
- Penicillamine
- Pentamidine
- Perphenazine
- Perphenazine; Amitriptyline
- Phenylephrine; Promethazine
- Pimavanserin
- Pimozide
- Pirbuterol
- Pitolisant
- Posaconazole
- Primaquine
- Procainamide
- Prochlorperazine
- Promethazine
- Propafenone
- Protriptyline
- Quetiapine
- Quinidine
- Quinine
- Ranolazine
- Ribociclib
- Ribociclib; Letrozole
- Rilpivirine
- Risperidone
- Romidepsin
- Salmeterol
- Saquinavir
- Selpercatinib
- Sertraline
- Sevoflurane
- Short-acting beta-agonists
- Siponimod
- Solifenacin
- Sorafenib
- Sotalol
- Sunitinib
- Tacrolimus
- Tamoxifen
- Telavancin
- Telithromycin
- Terbutaline
- Tetrabenazine
- Thioridazine
- Tiotropium; Olodaterol
- Tolterodine
- Toremifene
- Trazodone
- Triclabendazole
- Tricyclic antidepressants
- Trifluoperazine
- Trimipramine
- Triptorelin
- Tuberculin Purified Protein Derivative, PPD
- Umeclidinium; Vilanterol
- Vandetanib
- Vardenafil
- Vemurafenib
- Venlafaxine
- Voriconazole
- Vorinostat
- Ziprasidone
