Immune Globulin IV IVIG IGIV

Immune Globulin IV Brand Names

ASCENIV | BIVIGAM | Carimune | Carimune NF | Flebogamma | Flebogamma DIF | Gamimune N | Gammagard | Gammagard S/D | Gammaked | Gammaplex | Gammar-P IV | Gamunex | Gamunex-C | Iveegam | Iveegam EN | Octagam | Panglobulin | Panglobulin NF | panzyga | Polygam S/D | Privigen | Sandoglobulin | Venoglobulin-S | Vigam

What is Immune Globulin IV

Immune globulin IV (IVIG) is an intravenous solution composed primarily of human immunoglobulin G (IgG), with trace amounts of IgA and IgM.

IVIG is derived from the pooled human plasma of thousands of donors, ensuring a diversified collection of antibodies with variable antigen-binding regions.

All samples undergo human immunodeficiency virus (HIV), hepatitis B, and hepatitis C testing. Although the amount of each IgG subclass is similar to that of human plasma in all IVIG formulations, titers among specific antigens, preparation methods, viral inactivation steps, stabilizing agents, osmolality, and IgA content differ among products.

Thus, IVIG products have comparable efficacy but are not pharmaceutically equivalent. IVIG is used for a variety of conditions; its primary indication is as replacement therapy for patients with antibody deficiencies.

IVIG is used to provide immediate passive immunity after suspected exposure to an organism for which no active immunization exists or if there is inadequate time to develop active immunization, and as replacement therapy for patients with antibody deficiencies.

IVIG also has been used successfully to treat immune thrombocytopenic purpura (ITP), Kawasaki syndrome (mucocutaneous lymph node syndrome), and chronic inflammatory demyelinating polyneuropathies (CIDP).

It has been used for a variety of other clinical conditions. Intravenous immune globulins have been available since the late 1980s, and many products are commercially available.

Indications

1. acute disseminated encephalomyelitis
2. agammaglobulinemia
3. bacterial infection prophylaxis
4. chronic inflammatory demyelinating polyneuropathy (CIDP)
5. dermatomyositis
6. encephalitis
7. Guillain-Barre syndrome
8. hyperbilirubinemia
9. hypogammaglobulinemia
10. immune thrombocytopenic purpura (ITP)
11. Kawasaki disease
12. measles prophylaxis
13. meningitis
14. multifocal motor neuropathy
15. multisystem inflammatory syndrome in children (MIS-C)
16. myasthenia gravis
17. myocarditis
18. pemphigus
19. post-transfusion purpura
20. sepsis
21. Stevens-Johnson syndrome
22. tetanus
23. thrombocytopenia
24. toxic epidermal necrolysis
25. varicella (chickenpox) infection prophylaxis
26. West Nile virus infection

Side Effects

1. abdominal pain
2. acute respiratory distress syndrome (ARDS)
3. agitation
4. alopecia
5. anaphylactic shock
6. anaphylactoid reactions
7. anemia
8. angioedema
9. anorexia
10. anuria
11. anxiety
12. apnea
13. arthralgia
14. aseptic meningitis
15. asthenia
16. azotemia
17. back pain
18. bleeding
19. bradycardia
20. bronchospasm
21. bullous rash
22. candidiasis
23. cardiac arrest
24. chest pain (unspecified)
25. chills
26. coma
27. conjunctivitis
28. cough
29. cyanosis
30. cystitis
31. dental pain
32. diaphoresis
33. diarrhea
34. disseminated intravascular coagulation (DIC)
35. dizziness
36. drowsiness
37. dyspepsia
38. dyspnea
39. dysuria
40. ecchymosis
41. eczema vaccinatum
42. edema
43. elevated hepatic enzymes
44. enterocolitis
45. epistaxis
46. erythema
47. erythema multiforme
48. fatigue
49. fever
50. flushing
51. gastroesophageal reflux
52. headache
53. hematuria
54. hemolysis
55. hemolytic anemia
56. hepatitis
57. hot flashes
58. hyperbilirubinemia
59. hyperhidrosis
60. hypertension
61. hypoglycemia
62. hyponatremia
63. hypotension
64. hypoxia
65. infection
66. influenza
67. infusion-related reactions
68. injection site reaction
69. insomnia
70. jaundice
71. leukopenia
72. lymphadenopathy
73. maculopapular rash
74. malaise
75. migraine
76. musculoskeletal pain
77. myalgia
78. myocardial infarction
79. nasal congestion
80. nausea
81. ocular discharge
82. ocular irritation
83. ocular pain
84. oliguria
85. osmotic nephrosis
86. otalgia
87. pallor
88. palpitations
89. pancytopenia
90. paresis
91. paresthesias
92. petechiae
93. pharyngitis
94. phlebitis
95. photophobia
96. pruritus
97. pulmonary edema
98. pulmonary embolism
99. purpura
100. rash
101. renal failure (unspecified)
102. renal tubular necrosis
103. retinal thrombosis
104. rhinitis
105. rhinorrhea
106. seizures
107. sinus tachycardia
108. sinusitis
109. Stevens-Johnson syndrome
110. stroke
111. synovitis
112. throat irritation
113. thrombocytopenia
114. thromboembolism
115. thrombosis
116. tremor
117. urticaria
118. visual impairment
119. vomiting
120. wheezing

Monitoring Parameters

• serum creatinine/BUN
• serum IgG concentations

Contraindications

• agammaglobulinemia
• albumin hypersensitivity
• aseptic meningitis
• breast-feeding
• cardiac disease
• corn hypersensitivity
• coronary artery disease
• dehydration
• diabetes mellitus
• geriatric
• heart failure
• hemolysis
• hereditary fructose intolerance
• hyperprolinemia
• hypertension
• hypertriglyceridemia
• hypervolemia
• hypogammaglobulinemia
• hyponatremia
• hypovolemia
• IgA deficiency
• infants
• infusion-related reactions
• maltose hypersensitivity
• migraine
• neonates
• obesity
• pregnancy
• renal disease
• renal failure
• renal impairment
• sepsis
• subcutaneous administration
• thromboembolism
• vaccination
• viral infection

Interactions

• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acyclovir
• Adefovir
• Amikacin
• Aminoglycosides
• Amlodipine; Celecoxib
• Amphotericin B
• Amphotericin B cholesteryl sulfate complex (ABCD)
• Amphotericin B lipid complex (ABLC)
• Amphotericin B liposomal (LAmB)
• Aspirin, ASA
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Caffeine; Orphenadrine
• Aspirin, ASA; Carisoprodol
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Citric Acid; Sodium Bicarbonate
• Aspirin, ASA; Dipyridamole
• Aspirin, ASA; Omeprazole
• Aspirin, ASA; Oxycodone
• Aspirin, ASA; Pravastatin
• Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Bacitracin
• Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Bismuth Subsalicylate
• Bismuth Subsalicylate; Metronidazole; Tetracycline
• Capreomycin
• Celecoxib
• Choline Salicylate; Magnesium Salicylate
• Cidofovir
• Cisplatin
• Colistimethate, Colistin, Polymyxin E
• Cyclosporine
• Diclofenac
• Diclofenac; Misoprostol
• Diflunisal
• Diphenhydramine; Ibuprofen
• Diphenhydramine; Naproxen
• Esomeprazole; Naproxen
• Etodolac
• Famotidine; Ibuprofen
• Fenoprofen
• Flurbiprofen
• Foscarnet
• Ganciclovir
• Gentamicin
• Hydrocodone; Ibuprofen
• Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
• Ibuprofen
• Ibuprofen; Oxycodone
• Ibuprofen; Pseudoephedrine
• Indomethacin
• Kanamycin
• Ketoprofen
• Ketorolac
• Lansoprazole; Naproxen
• Magnesium Salicylate
• Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
• Measles/Mumps/Rubella Vaccines, MMR
• Meclofenamate Sodium
• Mefenamic Acid
• Meloxicam
• Nabumetone
• Naproxen
• Naproxen; Pseudoephedrine
• Naproxen; Sumatriptan
• Nonsteroidal antiinflammatory drugs
• Oxaprozin
• Pamidronate
• Paromomycin
• Pentamidine
• Piroxicam
• Plazomicin
• Polymyxin B
• Polymyxins
• Rofecoxib
• Rotavirus Vaccine
• Rubella Virus Vaccine Live
• Salsalate
• Streptomycin
• Streptozocin
• Sulindac
• Tacrolimus
• Tobramycin
• Tolmetin
• Valacyclovir
• Valdecoxib
• Valganciclovir
• Vancomycin
• Varicella-Zoster Virus Vaccine, Live
• Zoledronic Acid