How to avoid precipitating gout flares when initiating ULT?
- • Gradual dose increases. Start at 100 mg/day and increase by 100-mg increments (or 50 mg if glomerular filtration rate [GFR] <30 mL/minute), every 2 to 4 weeks.
- • Use of prophylaxis with colchicine, nonsteroidal antiinflammatory drugs (NSAIDs) or low-dose prednisone
