Gadobenate Dimeglumine Brand Name– Multihance
What is Gadobenate Dimeglumine
Gadobenate dimeglumine is a paramagnetic agent used during magnetic resonance imaging (MRI) for enhanced visualization of abnormal vascularity within the central nervous system or disruptions in the blood-brain barrier, and during magnetic resonance angiography (MRA) to evaluate occlusive disease within the renal and aorto-iliac-femoral vasculature.
Like all gadolinium-based contrast agents (GBCAs), gadobenate dimeglumine carries a black box warning for nephrogenic systemic fibrosis (NSF). NSF is a serious condition that may result in fatal or debilitating fibrosis of the skin, muscle, and internal organs.
The propensity to cause NSF differs among available GBCAs; few, if any, confirmed cases have been associated with gadobenate dimeglumine while most unconfounded cases have been reported with gadodiamide, gadopentetate dimeglumine, and gadoversetamide
Indications
- angiography
- magnetic resonance imaging (MRI)
For use as a contrast enhancement in magnetic resonance imaging (MRI) to visualize areas of the brain, spine, and associated tissues with disruption of the blood brain barrier or abnormal vascularity
Side Effects
- abdominal pain
- anaphylactoid reactions
- angioedema
- asthenia
- AV block
- cardiac arrest
- chest pain (unspecified)
- chills
- diarrhea
- dizziness
- dysgeusia
- fatigue
- fever
- headache
- hyperemia
- hyperhidrosis
- injection site reaction
- laryngospasm
- malaise
- nasal congestion
- nausea
- nephrogenic systemic fibrosis (nephrogenic fibrosing dermopathy)
- ocular inflammation
- ocular pruritus
- pancreatitis
- paresthesias
- parosmia
- pruritus
- pulmonary edema
- QT prolongation
- rash
- renal failure (unspecified)
- respiratory arrest
- sneezing
- tremor
- urticaria
- visual impairment
- vomiting
- wheezing
- xerostomia
Monitoring Parameters
- serum creatinine/BUN
Contraindications
- asthma
- atopy
- breast-feeding
- cardiac arrhythmias
- children
- diabetes mellitus
- dialysis
- extravasation
- geriatric
- hypertension
- infants
- magnetic resonance imaging (MRI)
- neonates
- nephrogenic systemic fibrosis (nephrogenic fibrosing dermopathy)
- pregnancy
- QT prolongation
- radiopaque contrast media hypersensitivity
- renal disease
- renal failure
- renal impairment
- sickle cell disease
Interactions
- Anthracyclines
- Cisplatin
- Daunorubicin
- Doxorubicin
- Epirubicin
- Etoposide, VP-16
- Idarubicin
- Methotrexate
- Paclitaxel
- Vinca alkaloids
