Ferric carboxymaltose Brand Name– Injectafer
What is Ferric carboxymaltose
Ferric carboxymaltose is a parenteral iron replacement product for the treatment of iron deficiency anemia.
Ferric carboxymaltose is for use in adults who have had intolerance to oral iron or unsatisfactory response to oral iron or those who have non-dialysis dependent chronic kidney disease.
Ferric carboxymaltose, a non-dextran intravenous iron therapy, may be used to treat iron deficiency anemia caused by several underlying conditions including heavy menstrual bleeding, pregnancy, childbirth, inflammatory bowel disease, other malabsorption diseases, bariatric surgery, or chronic kidney disease.
Due to reports of anaphylactic-type reactions, some life-threatening and fatal, patients should be monitored for signs and symptoms of hypersensitivity during and after administration for at least 30 minutes and until clinically stable following completion of the infusion.
Ferric carboxymaltose was FDA-approved in July 2013.
Indications
- iron-deficiency anemia
For the treatment of iron-deficiency anemia in patients who are intolerant to or have had an unsatisfactory response to oral iron, or those who have non-dialysis dependent chronic kidney disease
Side Effects
- abdominal pain
- anaphylactic shock
- anaphylactoid reactions
- arthralgia
- back pain
- chest pain (unspecified)
- chills
- constipation
- diarrhea
- dizziness
- dysgeusia
- dyspnea
- elevated hepatic enzymes
- erythema
- fever
- flushing
- headache
- hypertension
- hypophosphatemia
- hypotension
- injection site reaction
- nausea
- osteomalacia
- paresthesias
- pruritus
- rash
- sinus tachycardia
- skin discoloration
- sneezing
- syncope
- urticaria
- vomiting
- wheezing
Monitoring Parameters
- ferritin
- hemoglobin/hematocrit
- serum iron
- serum phosphate
- transferrin
Contraindications
- breast-feeding
- hemochromatosis
- hemoglobinopathy
- hemosiderosis
- hepatic disease
- hyperparathyroidism
- hypophosphatemia
- malnutrition
- pregnancy
- vitamin D deficiency
Interactions
- Darbepoetin Alfa
- Deferasirox
- Deferiprone
- Deferoxamine
- Dimercaprol
- Epoetin Alfa
- Iron
- Methoxy polyethylene glycol-epoetin beta
