Felodipine

Felodipine Brand Name– Plendil

What is Felodipine

Felodipine is an oral calcium-channel blocker used in the treatment of hypertension.

It is a member of the dihydropyridine class and is a potent peripheral vasodilator similar to nifedipine, isradipine, and amlodipine. Felodipine has greater selectivity for vascular smooth muscle relative to myocardial muscle than does nifedipine.

Felodipine was approved by the FDA in July 1991 for the treatment of hypertension.

Indications

• angina
• hypertension

For the treatment of hypertension

Side Effects

1. anemia
2. angina
3. angioedema
4. anxiety
5. asthenia
6. back pain
7. constipation
8. cough
9. depression
10. diarrhea
11. dizziness
12. dyspnea
13. dysuria
14. elevated hepatic enzymes
15. epistaxis
16. erythema
17. flushing
18. gingival hyperplasia
19. gynecomastia
20. headache
21. heart failure
22. hypotension
23. impotence (erectile dysfunction)
24. increased urinary frequency
25. infection
26. influenza
27. insomnia
28. irritability
29. libido decrease
30. nausea
31. palpitations
32. paresthesias
33. peripheral edema
34. peripheral vasodilation
35. pharyngitis
36. polyuria
37. pyrosis (heartburn)
38. rash
39. rhinorrhea
40. sinus tachycardia
41. sinusitis
42. sneezing
43. syncope
44. urinary urgency
45. urticaria
46. vasculitis
47. vomiting

Monitoring Parameters

• blood pressure
• heart rate

Contraindications

• acute myocardial infarction
• angina
• aortic stenosis
• bradycardia
• breast-feeding
• cardiogenic shock
• children
• coronary artery disease
• dihydropyridine hypersensitivity
• gastroesophageal reflux disease (GERD)
• geriatric
• heart failure
• hepatic disease
• hiatal hernia
• hypotension
• labor
• pregnancy
• ventricular dysfunction

Interactions

• Acebutolol
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Dichloralphenazone; Isometheptene
• Acetaminophen; Guaifenesin; Phenylephrine
• Acetaminophen; Pseudoephedrine
• Acrivastine; Pseudoephedrine
• Aldesleukin, IL-2
• Alemtuzumab
• Alfentanil
• Alfuzosin
• Alprostadil
• Amifostine
• Aminolevulinic Acid
• Amiodarone
• Amlodipine; Celecoxib
• Amoxicillin; Clarithromycin; Lansoprazole
• Amoxicillin; Clarithromycin; Omeprazole
• Amphetamine; Dextroamphetamine Salts
• Amprenavir
• Amyl Nitrite
• Apalutamide
• Apomorphine
• Apraclonidine
• Aprepitant, Fosaprepitant
• Aripiprazole
• Asenapine
• Atazanavir
• Atazanavir; Cobicistat
• Atenolol
• Atenolol; Chlorthalidone
• Baclofen
• Barbiturates
• Bendroflumethiazide; Nadolol
• Benzonatate
• Benzphetamine
• Betaxolol
• Bictegravir; Emtricitabine; Tenofovir Alafenamide
• Bisoprolol
• Bisoprolol; Hydrochlorothiazide, HCTZ
• Boceprevir
• Bortezomib
• Bosentan
• Brigatinib
• Brimonidine; Timolol
• Brompheniramine; Carbetapentane; Phenylephrine
• Brompheniramine; Dextromethorphan; Phenylephrine
• Brompheniramine; Hydrocodone; Pseudoephedrine
• Brompheniramine; Pseudoephedrine
• Cabergoline
• Carbamazepine
• Carbetapentane; Chlorpheniramine; Phenylephrine
• Carbetapentane; Diphenhydramine; Phenylephrine
• Carbetapentane; Guaifenesin; Phenylephrine
• Carbetapentane; Phenylephrine
• Carbetapentane; Phenylephrine; Pyrilamine
• Carbetapentane; Pseudoephedrine
• Carbidopa; Levodopa
• Carbidopa; Levodopa; Entacapone
• Carbinoxamine; Dextromethorphan; Pseudoephedrine
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Hydrocodone; Pseudoephedrine
• Carbinoxamine; Phenylephrine
• Carbinoxamine; Pseudoephedrine
• Cariprazine
• Carteolol
• Carvedilol
• Celecoxib
• Ceritinib
• Cetirizine; Pseudoephedrine
• Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
• Chlophedianol; Guaifenesin; Phenylephrine
• Chloroprocaine
• Chlorpheniramine; Dextromethorphan; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Phenylephrine
• Chlorpheniramine; Pseudoephedrine
• Cimetidine
• Ciprofloxacin
• Clarithromycin
• Co-Enzyme Q10, Ubiquinone
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• Cobimetinib
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• Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
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• Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
• Dexmedetomidine
• Dexmethylphenidate
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• Dextromethorphan; Guaifenesin; Phenylephrine
• Dextromethorphan; Guaifenesin; Pseudoephedrine
• Dextromethorphan; Quinidine
• Diazoxide
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• Dorzolamide; Timolol
• Dronedarone
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• Drospirenone; Ethinyl Estradiol; Levomefolate
• Duloxetine
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• Etodolac
• Etomidate
• Famotidine; Ibuprofen
• Fedratinib
• Fenoprofen
• Fentanyl
• Fexofenadine; Pseudoephedrine
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• Fluconazole
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• Flurbiprofen
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• Fosamprenavir
• Fospropofol
• General anesthetics
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• Ginseng, Panax ginseng
• grapefruit juice
• Guaifenesin; Hydrocodone; Pseudoephedrine
• Guaifenesin; Phenylephrine
• Guaifenesin; Pseudoephedrine
• Haloperidol
• Halothane
• Hydantoins
• Hydralazine; Isosorbide Dinitrate, ISDN
• Hydrochlorothiazide, HCTZ; Metoprolol
• Hydrocodone; Ibuprofen
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Ibuprofen
• Ibuprofen; Oxycodone
• Ibuprofen; Pseudoephedrine
• Idelalisib
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• Iloprost
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• Intravenous Lipid Emulsions
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• Isoniazid, INH; Rifampin
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• Istradefylline
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• Ivacaftor
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• Ketamine
• Ketoconazole
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• Labetalol
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• Lanreotide
• Lansoprazole; Naproxen
• Lapatinib
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• Lesinurad
• Lesinurad; Allopurinol
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• Levodopa
• Lisdexamfetamine
• Lithium
• Loperamide
• Loperamide; Simethicone
• Lopinavir; Ritonavir
• Loratadine; Pseudoephedrine
• Lovastatin; Niacin
• Lumacaftor; Ivacaftor
• Lumacaftor; Ivacaftor
• Lurasidone
• Meclofenamate Sodium
• Mefenamic Acid
• Melatonin
• Meloxicam
• Mestranol; Norethindrone
• Methamphetamine
• Methoxsalen
• Methylphenidate
• Methysergide
• Metoprolol
• Mifepristone
• Milrinone
• Mitotane
• Nabumetone
• Nadolol
• Naproxen
• Naproxen; Pseudoephedrine
• Naproxen; Sumatriptan
• Nebivolol
• Nebivolol; Valsartan
• Nefazodone
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• Neuromuscular blockers
• Nevirapine
• Niacin, Niacinamide
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• Nitrates
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• Nonsteroidal antiinflammatory drugs
• Octreotide
• Olanzapine
• Ombitasvir; Paritaprevir; Ritonavir
• Omeprazole; Amoxicillin; Rifabutin
• Oritavancin
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• Oxcarbazepine
• Oxymetazoline
• Palbociclib
• Paliperidone
• Pasireotide
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• Penbutolol
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• Phenelzine
• Phenylephrine
• Phenylephrine; Promethazine
• Photosensitizing agents (topical)
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• Posaconazole
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• Procainamide
• Procaine
• Propofol
• Protease inhibitors
• Pseudoephedrine
• Quinidine
• Rasagiline
• Remifentanil
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• Ribociclib; Letrozole
• Rifabutin
• Rifampin
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• Risperidone
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• Rofecoxib
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• Selegiline
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• Sevoflurane
• Silodosin
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• Tenofovir Alafenamide
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