Felbamate Brand Name– Felbatol
What is Felbamate
Felbamate is an oral anticonvulsant agent. It is approved for the treatment of partial seizures in adults and Lennox-Gastaut syndrome in children and adults.
It is chemically similar to meprobamate, an anxiolytic agent, but felbamate does not possess muscle-relaxant activity.
Felbamate is effective as both add-on and monotherapy, has a broad spectrum of activity, and, at present, shows no teratogenicity in animal screening.
Felbamate was approved by the FDA in July 1993. In 1994, the occurrence of aplastic anemia and later, acute hepatic failure, limited the use of felbamate to treatment of seizures refractory to other agents.
Indications
- Lennox-Gastaut syndrome
- partial seizures
For the treatment of partial seizures with or without generalization in adults
NOTE: Felbamate has not been systematically studied as initial monotherapy.
Side Effects
- abdominal pain
- acne vulgaris
- agitation
- agranulocytosis
- alopecia
- anaphylactoid reactions
- anorexia
- anxiety
- aplastic anemia
- appetite stimulation
- arthralgia
- asthenia
- ataxia
- atrial fibrillation
- bradycardia
- bronchospasm
- bullous rash
- cardiac arrest
- cerebral edema
- chest pain (unspecified)
- choreoathetosis
- coma
- confusion
- conjunctivitis
- constipation
- cough
- dehydration
- depression
- diarrhea
- diplopia
- disseminated intravascular coagulation (DIC)
- dizziness
- drowsiness
- drug-induced body odor
- dysarthria
- dysgeusia
- dyskinesia
- dyspepsia
- dysphagia
- dyspnea
- dystonic reaction
- dysuria
- edema
- elevated hepatic enzymes
- emotional lability
- encephalopathy
- eosinophilia
- epistaxis
- esophagitis
- euphoria
- fatigue
- fetal death
- fever
- flatulence
- gastritis
- gastroesophageal reflux
- GI bleeding
- GI obstruction
- glossitis
- hallucinations
- headache
- heart failure
- hematemesis
- hematuria
- hemolytic anemia
- hemolytic-uremic syndrome
- hepatic failure
- hepatitis
- hepatotoxicity
- hiccups
- hyperammonemia
- hyperglycemia
- hyperhidrosis
- hypernatremia
- hyperphosphatemia
- hypertension
- hypocalcemia
- hypoglycemia
- hypokalemia
- hypomagnesemia
- hyponatremia
- hypophosphatemia
- hypotension
- hypothermia
- hypoxia
- ileus
- insomnia
- jaundice
- leukocytosis
- leukopenia
- livedo reticularis
- lymphadenopathy
- malaise
- mania
- menstrual irregularity
- migraine
- miosis
- myalgia
- myasthenia
- nausea
- nystagmus
- palpitations
- pancreatitis
- pancytopenia
- paranoia
- paresthesias
- peptic ulcer
- pharyngitis
- photosensitivity
- pleural effusion
- pneumonitis
- pruritus
- psychosis
- purpura
- rash
- renal failure (unspecified)
- respiratory depression
- rhabdomyolysis
- rhinitis
- SIADH
- sinus tachycardia
- sinusitis
- Stevens-Johnson syndrome
- stomatitis
- suicidal ideation
- supraventricular tachycardia (SVT)
- thrombocytopenia
- torsade de pointes
- toxic epidermal necrolysis
- tremor
- urinary incontinence
- urinary retention
- urticaria
- vaginal bleeding
- vasculitis
- visual impairment
- vomiting
- weight gain
- weight loss
- xerostomia
Monitoring Parameters
- CBC with differential
- LFTs
- platelet count
- serum iron
Contraindications
- abrupt discontinuation
- agranulocytosis
- aplastic anemia
- bone marrow suppression
- breast-feeding
- carbamate hypersensitivity
- children
- depression
- geriatric
- hematological disease
- hepatic disease
- hepatitis
- hepatotoxicity
- infants
- jaundice
- leukopenia
- neutropenia
- pregnancy
- renal failure
- renal impairment
- suicidal ideation
- thrombocytopenia
Interactions
- Abacavir; Dolutegravir; Lamivudine
- Alprazolam
- Amoxapine
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphetamine; Dextroamphetamine Salts
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Atazanavir
- Atazanavir; Cobicistat
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Bedaquiline
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bupivacaine; Lidocaine
- Bupropion
- Bupropion; Naltrexone
- Cannabidiol
- Carbamazepine
- Carisoprodol
- Citalopram
- Clarithromycin
- Clobazam
- Clopidogrel
- Cobicistat
- Cobimetinib
- Colesevelam
- Dapsone
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Deferiprone
- Dolutegravir
- Dolutegravir; Lamivudine
- Dolutegravir; Rilpivirine
- Doxorubicin
- Dronabinol
- Elbasvir; Grazoprevir
- Elvitegravir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Escitalopram
- Esomeprazole
- Esomeprazole; Naproxen
- Estrogens
- Ethanol
- Guanidine
- Hydantoins
- Hydroxychloroquine
- Isavuconazonium
- Isocarboxazid
- Ivabradine
- Lacosamide
- Lidocaine
- Lidocaine; Prilocaine
- Lisdexamfetamine
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Maprotiline
- Maraviroc
- Mefloquine
- Methsuximide
- Molindone
- Monoamine oxidase inhibitors
- Ombitasvir; Paritaprevir; Ritonavir
- Pemoline
- Phenelzine
- Phenobarbital
- Phenothiazines
- Phentermine; Topiramate
- Praziquantel
- Progestins
- Ritonavir
- Rivaroxaban
- Selegiline
- Simeprevir
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Terbinafine
- Topiramate
- Tranylcypromine
- Tretinoin, ATRA
- Tricyclic antidepressants
- Ulipristal
- Valproic Acid, Divalproex Sodium
- Vasopressin, ADH
- Vincristine
- Vincristine Liposomal
- Vorapaxar
- Voriconazole
- Zonisamide
