Etodolac

Etodolac Brand Name– Lodine | Lodine XL

What is Etodolac

Etodolac is a nonsteroidal anti-inflammatory drug (NSAID) of the indole and indene acetic acid chemical class.

Etodolac has analgesic and antipyretic activity. Etodolac is available as a racemic mixture of the (-)R- and (+)S-etodolac; however, only the (+)S form is biologically active.

Etodolac is indicated for use in the management of osteoarthritis, rheumatoid arthritis, and the control of acute pain.

All NSAIDs including etodolac cause an increased risk of serious gastrointestinal adverse effects including bleeding, ulceration, and perforation of the stomach or intestines and may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke.

The lowest effective etodolac dose for the shortest possible duration is recommended, as the risk for adverse effects may increase with duration of use.

Etodolac was originally approved by the FDA in January 1991 for the treatment of osteoarthritis and was subsequently approved for the treatment of rheumatoid arthritis in July 1996.

A sustained-release formulation, Lodine® XL, was FDA-approved in October 1996 for the management of signs and symptoms of osteoarthritis and rheumatoid arthritis.

Indications

1. arthralgia
2. bone pain
3. dental pain
4. juvenile rheumatoid arthritis (JRA)/juvenile idiopathic arthritis (JIA)
5. mild pain
6. moderate pain
7. myalgia
8. osteoarthritis
9. rheumatoid arthritis

For the treatment of mild pain or moderate pain including arthralgia, myalgia, dental pain, or bone pain

Side Effects

1. abdominal pain
2. agranulocytosis
3. alopecia
4. anaphylactic shock
5. anaphylactoid reactions
6. anemia
7. angioedema
8. anorexia
9. anxiety
10. aplastic anemia
11. arrhythmia exacerbation
12. arthralgia
13. aseptic meningitis
14. asthenia
15. azotemia
16. blurred vision
17. bronchospasm
18. bullous rash
19. cholestasis
20. colitis
21. coma
22. confusion
23. conjunctivitis
24. constipation
25. cystitis
26. depression
27. diaphoresis
28. diarrhea
29. dizziness
30. dysgeusia
31. dyspepsia
32. dysphagia
33. dyspnea
34. dysuria
35. ecchymosis
36. elevated hepatic enzymes
37. eosinophilia
38. eructation
39. erythema multiforme
40. esophageal stricture
41. esophageal ulceration
42. esophagitis
43. exfoliative dermatitis
44. fatigue
45. flatulence
46. flushing
47. gastritis
48. GI bleeding
49. GI perforation
50. glossitis
51. hallucinations
52. headache
53. hearing loss
54. heart failure
55. hematemesis
56. hematuria
57. hemolytic anemia
58. hepatic failure
59. hepatic necrosis
60. hepatitis
61. hyperglycemia
62. hyperkalemia
63. hypertension
64. hyperuricemia
65. hyponatremia
66. increased urinary frequency
67. infection
68. insomnia
69. interstitial nephritis
70. irritability
71. jaundice
72. leukopenia
73. leukorrhea
74. lymphadenopathy
75. maculopapular rash
76. malaise
77. melena
78. myalgia
79. myocardial infarction
80. nausea
81. nephrolithiasis
82. nephrotic syndrome
83. neutropenia
84. odynophagia
85. oliguria
86. palpitations
87. pancreatitis
88. pancytopenia
89. paresthesias
90. peptic ulcer
91. pharyngitis
92. photophobia
93. photosensitivity
94. platelet dysfunction
95. polyuria
96. proteinuria
97. pruritus
98. purpura
99. pyrosis (heartburn)
100. rash
101. renal failure (unspecified)
102. renal papillary necrosis
103. respiratory depression
104. rhinitis
105. seizures
106. sinus tachycardia
107. sinusitis
108. skin hyperpigmentation
109. Stevens-Johnson syndrome
110. stomatitis
111. stroke
112. syncope
113. thrombocytopenia
114. thromboembolism
115. tinnitus
116. toxic epidermal necrolysis
117. tremor
118. urticaria
119. vasculitis
120. vertigo
121. vesicular rash
122. visual impairment
123. vomiting
124. weight gain
125. weight loss
126. xerostomia

Monitoring Parameters

• CBC
• LFTs
• serum creatinine/BUN
• stool guaiac

Contraindications

• acute bronchospasm
• acute myocardial infarction
• alcoholism
• anemia
• angina
• anticoagulant therapy
• asthma
• bone marrow suppression
• breast-feeding
• cardiac arrhythmias
• cardiac disease
• cardiomyopathy
• cerebrovascular disease
• chemotherapy
• children
• coagulopathy
• coronary artery bypass graft surgery (CABG)
• coronary artery disease
• corticosteroid therapy
• dehydration
• dental disease
• dental work
• diabetes mellitus
• edema
• geriatric
• GI bleeding
• GI disease
• GI perforation
• heart failure
• hematological disease
• hemophilia
• hepatic disease
• hypertension
• immunosuppression
• infants
• intramuscular injections
• jaundice
• labor
• myocardial infarction
• nasal polyps
• neonates
• neutropenia
• NSAID hypersensitivity
• peptic ulcer disease
• peripheral vascular disease
• pregnancy
• renal disease
• renal failure
• renal impairment
• rheumatoid arthritis
• salicylate hypersensitivity
• sepsis
• stroke
• surgery
• systemic lupus erythematosus (SLE)
• tachycardia
• thrombocytopenia
• thromboembolism
• tobacco smoking
• ulcerative colitis
• urticaria

Interactions

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