Ertugliflozin Sitagliptin Brand Name– Steglujan
What is Ertugliflozin Sitagliptin
Ertugliflozin sitagliptin is a combination of 2 oral antidiabetic agents.
Ertugliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor. Sitagliptin is a dipeptidyl-peptidase-4 (DPP-4) inhibitor.
The product used to improve glycemic control in adults with type 2 diabetes mellitus (DM). In clinical trials, when ertugliflozin was added to sitagliptin, a mean hemoglobin A1C reduction of 1.1% to 1.5% was attained.
When used in combination with metformin, many patients achieved their target A1C reductions.
SGLT2 therapy has been shown to reduce the incidence of heart failure (HF).
Like other SGLT2 inhibitor; DPP-4 inhibitor combinations, this drug product is not recommended for use in the presence of severe renal impairment, as ertugliflozin efficacy is reduced.
Metformin is first-line in the treatment of type 2 DM. Additional therapy with an SGLT2 inhibitor with evidence of reducing HF and/or chronic kidney disease (CKD) progression should be considered in patients with indicators of high-risk or established CKD or HF, independent of baseline A1C or individualized A1C target.
SGLT2 inhibitors with proven CV-risk reduction are also an alternative treatment option in DM patients with indicators of high-risk or established CV disease who cannot tolerate a glucagon-like peptide-1 receptor agonist (GLP-1 RA).
The DPP-4 inhibitors, like sitagliptin, are well tolerated, have a neutral effect on weight, and have minimal risk of hypoglycemia
Indications
- type 2 diabetes mellitus
For the treatment of type 2 diabetes mellitus in combination with diet and exercise
Side Effects
- abdominal pain
- anaphylactoid reactions
- angioedema
- arthralgia
- back pain
- balanitis
- bullous rash
- candidiasis
- constipation
- cystitis
- dehydration
- diabetic ketoacidosis
- diarrhea
- diuresis
- dysuria
- elevated hepatic enzymes
- exfoliative dermatitis
- headache
- heart failure
- hypercholesterolemia
- hyperlipidemia
- hyperphosphatemia
- hypoglycemia
- hypotension
- hypovolemia
- increased urinary frequency
- infection
- lower limb amputation
- myalgia
- nausea
- necrotizing fasciitis
- nocturia
- oral ulceration
- orthostatic hypotension
- pancreatitis
- pemphigus
- pharyngitis
- phimosis
- polydipsia
- polyuria
- pruritus
- rash
- renal failure (unspecified)
- rhabdomyolysis
- Stevens-Johnson syndrome
- stomatitis
- syncope
- tissue necrosis
- urinary urgency
- urticaria
- vaginitis
- vasculitis
- vomiting
- weight loss
Monitoring Parameters
- blood glucose
- glycosylated hemoglobin A1c (HbA1c)
- serum amylase
- serum cholesterol profile
- serum creatinine/BUN
- serum lipase
Contraindications
- adrenal insufficiency
- arthralgia
- balanitis
- breast-feeding
- burns
- cardiac disease
- children
- dehydration
- diabetic ketoacidosis
- dialysis
- exfoliative dermatitis
- fever
- geriatric
- heart failure
- hepatic disease
- history of angioedema
- hypercholesterolemia
- hypercortisolism
- hyperglycemia
- hyperthyroidism
- hypoglycemia
- hypotension
- hypothyroidism
- hypovolemia
- infants
- infection
- lower limb amputation
- malnutrition
- pancreatitis
- pituitary insufficiency
- pregnancy
- pyelonephritis
- renal failure
- renal impairment
- serious rash
- surgery
- tissue necrosis
- trauma
- type 1 diabetes mellitus
- urinary tract infection (UTI)
- vaginitis
Interactions
- Acebutolol
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Pseudoephedrine
- Acetazolamide
- Acrivastine; Pseudoephedrine
- Aliskiren; Valsartan
- Amlodipine; Benazepril
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphetamine
- Amphetamine; Dextroamphetamine
- Androgens
- Angiotensin II receptor antagonists
- Angiotensin-converting enzyme inhibitors
- Articaine; Epinephrine
- Atenolol
- Atenolol; Chlorthalidone
- atypical antipsychotic
- Azelastine; Fluticasone
- Azilsartan
- Azilsartan; Chlorthalidone
- Beclomethasone
- Benazepril
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Benzphetamine
- Beta-blockers
- Betamethasone
- Betaxolol
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Bortezomib
- Brimonidine; Timolol
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Budesonide
- Budesonide; Formoterol
- Bumetanide
- Candesartan
- Candesartan; Hydrochlorothiazide, HCTZ
- Captopril
- Captopril; Hydrochlorothiazide, HCTZ
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Carbonic anhydrase inhibitors
- Carteolol
- Carvedilol
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chloroquine
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorthalidone; Clonidine
- Chromium
- Ciclesonide
- Clarithromycin
- Clonidine
- Codeine; Phenylephrine; Promethazine
- Conjugated Estrogens
- Conjugated Estrogens; Bazedoxifene
- Conjugated Estrogens; Medroxyprogesterone
- Corticosteroids
- Cortisone
- Daclatasvir
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Deflazacort
- Desloratadine; Pseudoephedrine
- Dexamethasone
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmethylphenidate
- Dextroamphetamine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Diazoxide
- Dienogest; Estradiol valerate
- Diethylpropion
- Diethylstilbestrol, DES
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Phenylephrine
- Disopyramide
- Dobutamine
- Dopamine
- Dorzolamide; Timolol
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Ephedrine
- Epinephrine
- Eprosartan
- Eprosartan; Hydrochlorothiazide, HCTZ
- Erythromycin; Sulfisoxazole
- Esmolol
- Esterified Estrogens
- Esterified Estrogens; Methyltestosterone
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
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- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Estradiol; Progesterone
- Estrogens
- Estropipate
- Ethanol
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Fenofibrate
- Fenofibric Acid
- Fexofenadine; Pseudoephedrine
- Fibric acid derivatives
- Fludrocortisone
- Flunisolide
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Formoterol; Mometasone
- Fosinopril
- Fosinopril; Hydrochlorothiazide, HCTZ
- Furosemide
- Garlic, Allium sativum
- Gemfibrozil
- Glecaprevir; Pibrentasvir
- Green Tea
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Hydantoins
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydrocortisone
- Hydroxychloroquine
- Ibuprofen; Pseudoephedrine
- Indapamide
- Irbesartan
- Isocarboxazid
- Isoproterenol
- Labetalol
- Lanreotide
- Ledipasvir; Sofosbuvir
- Levobetaxolol
- Levobunolol
- Linezolid
- Lisdexamfetamine
- Lisinopril
- Lithium
- Lomefloxacin
- Lomitapide
- Loratadine; Pseudoephedrine
- Lorcaserin
- Losartan
- Lovastatin; Niacin
- Mecasermin rinfabate
- Mecasermin, Recombinant, rh-IGF-1
- Mepivacaine; Levonordefrin
- Mestranol; Norethindrone
- Methamphetamine
- Methazolamide
- Methylphenidate
- Methylprednisolone
- Metoprolol
- Metyrapone
- Midodrine
- Moexipril
- Mometasone
- Monoamine oxidase inhibitors
- Nadolol
- Naproxen; Pseudoephedrine
- Nebivolol
- Nebivolol; Valsartan
- Niacin, Niacinamide
- Niacin; Simvastatin
- Nicotine
- Norepinephrine
- Octreotide
- Olmesartan
- Orlistat
- Pasireotide
- Pegvisomant
- Pemoline
- Penbutolol
- Pentamidine
- Pentoxifylline
- Perindopril
- Perindopril; Amlodipine
- Phendimetrazine
- Phenelzine
- Phenothiazines
- Phentermine
- Phentermine; Topiramate
- Phenylephrine
- Phenylephrine; Promethazine
- Pindolol
- Prednisolone
- Prednisone
- Prilocaine; Epinephrine
- Progestins
- Propranolol
- Pseudoephedrine
- Pyrimethamine; Sulfadoxine
- Quinapril
- Quinolones
- Racepinephrine
- Ramipril
- Reserpine
- Ritodrine
- Sacubitril; Valsartan
- Salicylates
- Segesterone Acetate; Ethinyl Estradiol
- Selegiline
- Sofosbuvir
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Somatropin, rh-GH
- Sotalol
- Sparfloxacin
- Sulfadiazine
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulfasalazine
- Sulfisoxazole
- Sulfonamides
- Sympathomimetics
- Tacrolimus
- Tegaserod
- Telmisartan
- Thiazide diuretics
- Thyroid hormones
- Timolol
- tobacco
- Torsemide
- Trandolapril
- Trandolapril; Verapamil
- Tranylcypromine
- Triamcinolone
- Triamterene
- Trovafloxacin, Alatrofloxacin
- Valsartan
