Eribulin Brand Name– Halaven
What is Eribulin
Eribulin mesylate is a non-taxane, microtubule dynamics inhibitor with a distinct mechanism of action from other classes of tubulin-targeted agents such as the taxanes, vinca alkaloids, and epothilones.
It is a synthetic analogue of halichondrin B, a product isolated from the rare marine sponge Halichondria okadai. In a multicenter, randomized, comparative trial, eribulin was shown to significantly extend overall survival (OS) in previously treated metastatic breast cancer patients compared to other single agent therapeutic options.
Additionally, the median OS time was significantly improved with eribulin compared with dacarbazine in a subgroup of patients with previously treated, unresectable, advanced liposarcoma (n = 143) in a multinational, randomized, phase III trial.
In November 2010, eribulin mesylate received FDA approval for the treatment of metastatic breast cancer in patients who have previously received at least 2 chemotherapeutic regimens.
In January 2016, it was approved by the FDA for the treatment of unresectable or metastatic liposarcoma in patients who have received a prior anthracycline-containing regimen.
Indications
- breast cancer
- soft-tissue sarcoma
For the treatment of patients with breast cancer
for the treatment of metastatic breast cancer in patients who have previously received at least 2 chemotherapeutic regimens for the treatment of metastatic disease, including both an anthracycline and a taxane in either the adjuvant or metastatic setting
Side Effects
- abdominal pain
- abdominal pain
- alopecia
- anemia
- anemia
- anorexia
- anorexia
- anxiety
- arthralgia
- arthralgia
- asthenia
- asthenia
- back pain
- back pain
- bone pain
- bone pain
- constipation
- constipation
- cough
- dehydration
- depression
- diarrhea
- dizziness
- dysgeusia
- dyspepsia
- dyspnea
- dyspnea
- elevated hepatic enzymes
- elevated hepatic enzymes
- fatigue
- fatigue
- fever
- fever
- headache
- headache
- hyperbilirubinemia
- hyperglycemia
- hypocalcemia
- hypocalcemia
- hypokalemia
- hypokalemia
- hypomagnesemia
- hypophosphatemia
- hypophosphatemia
- hypotension
- infection
- infection
- insomnia
- lacrimation
- lymphopenia
- muscle cramps
- musculoskeletal pain
- myalgia
- myalgia
- nausea
- nausea
- neutropenia
- neutropenia
- pancreatitis
- paresthesias
- paresthesias
- peripheral edema
- peripheral neuropathy
- peripheral neuropathy
- pneumonitis
- pruritus
- QT prolongation
- rash
- Stevens-Johnson syndrome
- stomatitis
- stomatitis
- thrombocytopenia
- thrombocytopenia
- toxic epidermal necrolysis
- vomiting
- vomiting
- weakness
- weight loss
- weight loss
- xerosis
Monitoring Parameters
- CBC with differential
- ECG
- LFTs
- serum creatinine/BUN
- serum electrolytes
Contraindications
- apheresis
- AV block
- bradycardia
- breast-feeding
- cardiomyopathy
- celiac disease
- contraception requirements
- females
- fever
- geriatric
- heart failure
- hepatic disease
- hepatotoxicity
- human immunodeficiency virus (HIV) infection
- hyperparathyroidism
- hypocalcemia
- hypokalemia
- hypomagnesemia
- hypothermia
- hypothyroidism
- infertility
- long QT syndrome
- male-mediated teratogenicity
- myocardial infarction
- neutropenia
- peripheral neuropathy
- pheochromocytoma
- pregnancy
- QT prolongation
- renal disease
- renal impairment
- reproductive risk
- rheumatoid arthritis
- sickle cell disease
- sleep deprivation
- stroke
- systemic lupus erythematosus (SLE)
- thrombocytopenia
Interactions
- Abarelix
- Aclidinium; Formoterol
- Albuterol
- Albuterol; Ipratropium
- Alfuzosin
- Amiodarone
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Anagrelide
- Apomorphine
- Arformoterol
- Aripiprazole
- Arsenic Trioxide
- Artemether; Lumefantrine
- Asenapine
- Atomoxetine
- Azithromycin
- Bedaquiline
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Budesonide; Formoterol
- Buprenorphine
- Buprenorphine; Naloxone
- Ceritinib
- Chloroquine
- Chlorpromazine
- Ciprofloxacin
- Cisapride
- Citalopram
- Clarithromycin
- Class IA Antiarrhythmics
- Clofazimine
- Clozapine
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Crizotinib
- Dasatinib
- Degarelix
- Deutetrabenazine
- Dextromethorphan; Promethazine
- Diclofenac
- Diclofenac; Misoprostol
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Dofetilide
- Dolasetron
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Dronedarone
- Droperidol
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Eliglustat
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Encorafenib
- Entrectinib
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Esomeprazole; Naproxen
- Etodolac
- Ezogabine
- Famotidine; Ibuprofen
- Fenoprofen
- Fingolimod
- Flecainide
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Flurbiprofen
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvoxamine
- Formoterol
- Formoterol; Mometasone
- Foscarnet
- Gemifloxacin
- Gemtuzumab Ozogamicin
- Gilteritinib
- Glasdegib
- Glycopyrrolate; Formoterol
- Goserelin
- Granisetron
- Halogenated Anesthetics
- Haloperidol
- Histrelin
- Hydrocodone; Ibuprofen
- Hydroxychloroquine
- Hydroxyzine
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Ibutilide
- Iloperidone
- Indacaterol
- Indacaterol; Glycopyrrolate
- Indomethacin
- Inotuzumab Ozogamicin
- Itraconazole
- Ivosidenib
- Ketoconazole
- Ketoprofen
- Ketorolac
- Lansoprazole; Naproxen
- Lapatinib
- Lefamulin
- Lenvatinib
- Leuprolide
- Leuprolide; Norethindrone
- Levalbuterol
- Levofloxacin
- Lithium
- Lofexidine
- Long-acting beta-agonists
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Macimorelin
- Maprotiline
- Meclofenamate Sodium
- Mefenamic Acid
- Mefloquine
- Meloxicam
- Meperidine; Promethazine
- Mesoridazine
- Metaproterenol
- Methadone
- Metronidazole
- Midostaurin
- Mifepristone
- Mirtazapine
- Moxifloxacin
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nilotinib
- Norfloxacin
- Octreotide
- Ofloxacin
- Olanzapine
- Olodaterol
- Ondansetron
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Oxaprozin
- Ozanimod
- Palifermin
- Paliperidone
- Panobinostat
- Pasireotide
- Pazopanib
- Penicillamine
- Pentamidine
- Perphenazine
- Perphenazine; Amitriptyline
- Phenylephrine; Promethazine
- Pimavanserin
- Pimozide
- Pirbuterol
- Piroxicam
- Pitolisant
- Posaconazole
- Primaquine
- Prochlorperazine
- Promethazine
- Propafenone
- Quetiapine
- Quinine
- Ranolazine
- Ribociclib
- Ribociclib; Letrozole
- Rilpivirine
- Risperidone
- Romidepsin
- Salmeterol
- Saquinavir
- Selpercatinib
- Sertraline
- Short-acting beta-agonists
- Siponimod
- Solifenacin
- Sorafenib
- Sotalol
- Sulindac
- Sunitinib
- Tacrolimus
- Tamoxifen
- Telavancin
- Telithromycin
- Terbutaline
- Tetrabenazine
- Thioridazine
- Tiotropium; Olodaterol
- Tolmetin
- Tolterodine
- Toremifene
- Trazodone
- Triclabendazole
- Tricyclic antidepressants
- Trifluoperazine
- Triptorelin
- Tuberculin Purified Protein Derivative, PPD
- Umeclidinium; Vilanterol
- Vandetanib
- Vardenafil
- Vemurafenib
- Venlafaxine
- Voriconazole
- Vorinostat
- Ziprasidone
