Erdafitinib Brand Name– BALVERSA
What is Erdafitinib
Erdafitinib is a kinase inhibitor that inhibits FGFR1, FGFR2, FGFR3, and FGFR4.
It is indicated for the treatment of adult patients with locally advanced or metastatic urothelial carcinoma that has susceptible FGFR3 or FGFR2 genetic alterations and progressed during or following at least 1 line of platinum-containing chemotherapy including within 12 months of neoadjuvant or adjuvant platinum-containing chemotherapy based on a nonrandomized open-label study showing an objective response rate of 32.2% (complete response, 2.3%).
As a consequence of FGFR inhibition, erdafitinib is associated with hyperphosphatemia; dose adjustments are necessary based on the serum phosphate level.
Ocular disorders including central serous retinopathy/retinal pigment epithelial detachment (CSR/RPED) are also common; ophthalmological examinations should be performed regularly.
Indications
- urothelial carcinoma
For the treatment urothelial carcinoma
Side Effects
- abdominal pain
- abdominal pain
- alopecia
- anemia
- anemia
- anorexia
- arthralgia
- asthenia
- back pain
- blurred vision
- conjunctivitis
- constipation
- constipation
- corneal erosion
- diarrhea
- diarrhea
- dysgeusia
- dysgeusia
- dyspnea
- dyspnea
- elevated hepatic enzymes
- elevated hepatic enzymes
- fatigue
- fatigue
- fever
- fever
- foreign body sensation
- hematuria
- hematuria
- hypercalcemia
- hypercalcemia
- hyperglycemia
- hyperkalemia
- hyperphosphatemia
- hyperphosphatemia
- hypoalbuminemia
- hypomagnesemia
- hypomagnesemia
- hyponatremia
- hyponatremia
- hypophosphatemia
- hypophosphatemia
- infection
- infection
- keratitis
- lacrimation
- lethargy
- leukopenia
- malaise
- musculoskeletal pain
- nail discoloration
- nausea
- nausea
- neutropenia
- neutropenia
- onycholysis
- onycholysis
- palmar-plantar erythrodysesthesia (hand and foot syndrome)
- palmar-plantar erythrodysesthesia (hand and foot syndrome)
- renal failure (unspecified)
- retinal detachment
- retinal detachment
- retinopathy
- retinopathy
- stomatitis
- stomatitis
- thrombocytopenia
- thrombocytopenia
- vomiting
- vomiting
- weight loss
- xerophthalmia
- xerophthalmia
- xerosis
- xerostomia
Monitoring Parameters
- ophthalmologic exam
- pregnancy testing
- serum phosphate
Contraindications
- breast-feeding
- contraception requirements
- hyperphosphatemia
- infertility
- male-mediated teratogenicity
- ocular disease
- poor metabolizers
- pregnancy
- pregnancy testing
- reproductive risk
- visual disturbance
Interactions
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Alfentanil
- Alogliptin; Metformin
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Amiodarone
- Amobarbital
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Apalutamide
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Atazanavir
- Atazanavir; Cobicistat
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bexarotene
- Bosentan
- Brodalumab
- Burosumab
- Butabarbital
- Calcitriol
- Calcium Acetate
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Canagliflozin; Metformin
- Carbamazepine
- Cenobamate
- Ceritinib
- Chloramphenicol
- Clarithromycin
- Cobicistat
- Conivaptan
- Cyclosporine
- Dabrafenib
- Dapagliflozin; Metformin
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Dexamethasone
- Digoxin
- Dihydrotachysterol
- Dofetilide
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enzalutamide
- Ertugliflozin; Metformin
- Eslicarbazepine
- Etravirine
- Everolimus
- Fluconazole
- Fluorouracil, 5-FU
- Fosamprenavir
- Fosphenytoin
- Glipizide; Metformin
- Glyburide; Metformin
- grapefruit juice
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibritumomab Tiuxetan
- Idelalisib
- Indinavir
- Iron Sucrose, Sucroferric Oxyhydroxide
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ketoconazole
- Lanthanum Carbonate
- Linagliptin; Metformin
- Lopinavir; Ritonavir
- Lorlatinib
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Meloxicam
- Mephobarbital
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methenamine; Sodium Acid Phosphate
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methohexital
- Mifepristone
- Mitotane
- Modafinil
- Nafcillin
- Nefazodone
- Nelfinavir
- Nevirapine
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Pentobarbital
- Phenobarbital
- Phenytoin
- Posaconazole
- Potassium Phosphate
- Potassium Phosphate; Sodium Phosphate
- Primidone
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Rifaximin
- Ritonavir
- Saquinavir
- Secobarbital
- Sevelamer
- Sirolimus
- Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
- St. John’s Wort, Hypericum perforatum
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Tacrolimus
- Telithromycin
- Thiopental
- Tipranavir
- Tucatinib
- Valproic Acid, Divalproex Sodium
- Vincristine Liposomal
- Voriconazole
