Eprosartan Brand Name– Teveten
What is Eprosartan
Eprosartan is the third angiotensin II receptor antagonist to be approved in the US for the management of hypertension.
The other two, losartan and valsartan, were approved by the FDA in 1995 and 1996, respectively. Eprosartan lowers blood pressure in patients with essential hypertension.
Because eprosartan does not inhibit angiotensin converting enzyme (ACE), it does not result in bradykinin accumulation which is theorized to cause the cough and angioedema associated with ACE inhibitors.
However, angioedema has been rarely associated with eprosartan or other angiotensin II antagonists.
The FDA approved eprosartan (Teveten®) for the treatment of hypertension when dosed twice daily on 12/23/97; the FDA subsequently granted approval for eprosartan as a once or twice daily antihypertensive in October of 1998, and the product became available in October of 1999.
Indications
- hypertension
For the treatment of hypertension, either alone or in combination with other antihypertensive agents
Side Effects
- abdominal pain
- anaphylactoid reactions
- anemia
- angina
- angioedema
- anorexia
- arthralgia
- asthenia
- atrial fibrillation
- azotemia
- back pain
- blurred vision
- bradycardia
- chest pain (unspecified)
- conjunctivitis
- constipation
- cough
- cystitis
- dental pain
- diabetes mellitus
- diaphoresis
- diarrhea
- dizziness
- dyspepsia
- edema
- elevated hepatic enzymes
- epistaxis
- esophagitis
- fatigue
- fever
- flatulence
- furunculosis
- gastritis
- gingivitis
- gout
- headache
- hematuria
- hot flashes
- hypercholesterolemia
- hyperglycemia
- hyperkalemia
- hypertriglyceridemia
- hypokalemia
- hyponatremia
- hypotension
- increased urinary frequency
- leukopenia
- maculopapular rash
- malaise
- muscle cramps
- myalgia
- nausea
- nephrolithiasis
- neutropenia
- oliguria
- orthostatic hypotension
- palpitations
- pharyngitis
- polyuria
- pruritus
- purpura
- renal failure (unspecified)
- rhabdomyolysis
- rhinitis
- sinus tachycardia
- sinusitis
- teratogenesis
- thrombocytopenia
- tinnitus
- urinary incontinence
- vomiting
- xerophthalmia
- xerostomia
Monitoring Parameters
- blood pressure
- LFTs
- serum bilirubin (total and direct)
Contraindications
- ACE-inhibitor induced angioedema
- angioedema
- Black patients
- breast-feeding
- children
- geriatric
- heart failure
- hepatic disease
- hyperkalemia
- hypotension
- hypovolemia
- infants
- neonates
- pregnancy
- renal artery stenosis
- renal disease
- renal failure
- renal impairment
- surgery
Interactions
- Acarbose
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Pseudoephedrine
- Acrivastine; Pseudoephedrine
- Aldesleukin, IL-2
- Alemtuzumab
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Alogliptin; Metformin
- Alpha-glucosidase Inhibitors
- Alprostadil
- Amifostine
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Amobarbital
- Amphetamine; Dextroamphetamine Salts
- Amyl Nitrite
- Angiotensin II
- Angiotensin-converting enzyme inhibitors
- Apomorphine
- Apraclonidine
- Aripiprazole
- Asenapine
- Baclofen
- Benzphetamine
- Bosentan
- Brexpiprazole
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Cabergoline
- Calcium Phosphate, Supersaturated
- Canagliflozin; Metformin
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cariprazine
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chloroprocaine
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Clozapine
- Co-Enzyme Q10, Ubiquinone
- Cocaine
- Codeine; Phenylephrine; Promethazine
- Conivaptan
- Cyclosporine
- Dapagliflozin; Metformin
- Desloratadine; Pseudoephedrine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmethylphenidate
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Quinidine
- Diazoxide
- Diethylpropion
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Phenylephrine
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Duloxetine
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enflurane
- Ephedrine
- Eplerenone
- Epoprostenol
- Ertugliflozin; Metformin
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Etomidate
- Fexofenadine; Pseudoephedrine
- Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
- Fluoxetine; Olanzapine
- Fospropofol
- General anesthetics
- Glipizide; Metformin
- Glyburide; Metformin
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Haloperidol
- Halothane
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibritumomab Tiuxetan
- Ibuprofen; Pseudoephedrine
- Iloperidone
- Iloprost
- Incretin Mimetics
- Indapamide
- Insulins
- Intravenous Lipid Emulsions
- Isocarboxazid
- Isoflurane
- Isoproterenol
- Isosorbide Dinitrate, ISDN
- Isosorbide Mononitrate
- Ketamine
- Levodopa
- Linagliptin; Metformin
- Lisdexamfetamine
- Lithium
- Loop diuretics
- Loratadine; Pseudoephedrine
- Lovastatin; Niacin
- Lurasidone
- Magnesium Sulfate; Potassium Sulfate; Sodium Sulfate
- Meglitinides
- Mestranol; Norethindrone
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methamphetamine
- Methohexital
- Methylphenidate
- Miglitol
- Milrinone
- Naproxen; Pseudoephedrine
- Nateglinide
- Nefazodone
- Nesiritide, BNP
- Niacin, Niacinamide
- Niacin; Simvastatin
- Nitrates
- Nitroglycerin
- Nitroprusside
- Nonsteroidal antiinflammatory drugs
- Olanzapine
- Oxymetazoline
- Paliperidone
- Pentoxifylline
- Phenelzine
- Phenylephrine
- Phenylephrine; Promethazine
- Polyethylene Glycol; Electrolytes
- Polyethylene Glycol; Electrolytes; Ascorbic Acid
- Potassium
- Potassium Phosphate
- Potassium Phosphate; Sodium Phosphate
- Pramlintide
- Prazosin
- Procainamide
- Procaine
- Propofol
- Pseudoephedrine
- Quinidine
- Rasagiline
- Repaglinide
- Risperidone
- Selegiline
- Sevoflurane
- SGLT2 Inhibitors
- Silodosin
- Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Spironolactone
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulfonylureas
- Tetracaine
- Thiazolidinediones
- Thiopental
- Thiothixene
- Tizanidine
- Tolvaptan
- Tranylcypromine
- Trazodone
- Triamterene
- Trimethoprim
- Yohimbine
- Ziprasidone
