Entecavir Brand Name– Baraclude
What is Entecavir
Entecavir is a nucleoside analog indicated for the treatment of chronic hepatitis B virus (HBV) infection.
The drug is approved for use in nucleoside inhibitor-treatment-naive patients, lamivudine-resistant patients with compensated liver disease and evidence of active viral replication, and patients with decompensated liver disease.
Entecavir slows the progression of chronic HBV infection and improves liver inflammation and fibrosis caused by HBV.
Entecavir also displays weak activity against human immunodeficiency virus (HIV); however, it must not be considered an active component of a highly active antiretroviral (HAART) regimen.
Use of entecavir in HBV/HIV coinfected patients without the addition of a fully suppressive HIV treatment regimen may result in NRTI resistance
Indications
- hepatitis B infection
- hepatitis B virus
Side Effects
- abdominal pain
- alopecia
- anaphylactoid reactions
- ascites
- diarrhea
- dizziness
- drowsiness
- dyspepsia
- elevated hepatic enzymes
- fatigue
- fever
- glycosuria
- headache
- hematuria
- hepatic encephalopathy
- hepatitis B exacerbation
- hepatomegaly
- hepatotoxicity
- hyperbilirubinemia
- hyperglycemia
- hypoalbuminemia
- infection
- insomnia
- lactic acidosis
- nausea
- peripheral edema
- rash
- renal failure (unspecified)
- steatosis
- thrombocytopenia
- vomiting
Monitoring Parameters
- hepatitis B serology
- LFTs
- plasma HIV RNA
- serum creatinine/BUN
Contraindications
- breast-feeding
- children
- dialysis
- females
- geriatric
- hepatic disease
- hepatitis B and HIV coinfection
- hepatitis B exacerbation
- hepatotoxicity or lactic acidosis
- human immunodeficiency virus (HIV) infection
- infants
- neonates
- obesity
- organ transplant
- pregnancy
- renal failure
- renal impairment
Interactions
- Acyclovir
- Adefovir
- Alogliptin; Metformin
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminoglycosides
- Amlodipine; Benazepril
- Amphotericin B
- Amphotericin B cholesteryl sulfate complex (ABCD)
- Amphotericin B lipid complex (ABLC)
- Amphotericin B liposomal (LAmB)
- Angiotensin-converting enzyme inhibitors
- Benazepril
- Benazepril; Hydrochlorothiazide, HCTZ
- Canagliflozin; Metformin
- Capreomycin
- Captopril
- Captopril; Hydrochlorothiazide, HCTZ
- Cidofovir
- Cimetidine
- Cisplatin
- Colistimethate, Colistin, Polymyxin E
- Cyclosporine
- Dapagliflozin; Metformin
- Dextromethorphan; Quinidine
- Digoxin
- Dofetilide
- Donepezil; Memantine
- Echinacea
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Ertugliflozin; Metformin
- food
- Foscarnet
- Fosinopril
- Fosinopril; Hydrochlorothiazide, HCTZ
- Ganciclovir
- Glipizide; Metformin
- Glyburide; Metformin
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Triamterene
- Interferons
- Ketoconazole
- Linagliptin; Metformin
- Lisinopril
- Megestrol
- Memantine
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Midodrine
- Moexipril
- Morphine
- Morphine; Naltrexone
- Non-Ionic Contrast Media
- Nonsteroidal antiinflammatory drugs
- Orlistat
- Pamidronate
- Pancuronium
- Perindopril
- Perindopril; Amlodipine
- Polymyxins
- Procainamide
- Prochlorperazine
- Quinapril
- Quinidine
- Quinine
- Ramipril
- Ranitidine
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Tacrolimus
- Trandolapril
- Trandolapril; Verapamil
- Triamterene
- Trimethoprim
- Trospium
- Valacyclovir
- Valganciclovir
- Vancomycin
- Zoledronic Acid
