Drugs that cause hyperuricemia due to decreased renal excretion of urate
The mnemonic CAN’T LEAP can be used to remember these drugs:
- C yclosporine
- Alcohol
- Nicotinic acid
- Thiazides/Tacrolimus
- Lasix (furosemide) (and other loop diuretics)
- Ethambutol
- Aspirin (low dose)
- Pyrazinamide
Other drugs that can cause hyperuricemia include levodopa, theophylline, and didanosine. In contrast, the following commonly used drugs exert mild uricosuric effects and produce modest urate lowering: amlodipine, atorvastatin, fenofibrate, leflunomide, losartan, rosuvastatin, and high-dose salicylates.
