Doxorubicin Liposomal Brand Name– Doxil | Lipodox
What is Doxorubicin Liposomal
Liposomal doxorubicin is a cytotoxic anthracycline antibiotic that inhibits nucleotide replication by intercalation into DNA and RNA; it is also a topoisomerase II inhibitor.
Liposomal formulations incorporate the doxorubicin into a liposomal carrier.
Liposomal doxorubicin is indicated for the treatment of ovarian cancer after failure of platinum-based chemotherapy, AIDS-related Kaposi’s sarcoma after failure to or intolerance of prior systemic chemotherapy, and multiple myeloma in combination with bortezomib in patients who have not previously received bortezomib and have received at least 1 prior therapy.
Cardiomyopathy and infusion-related reactions have been reported with liposomal doxorubicin
Indications
- breast cancer
- cutaneous T-cell lymphoma (CTCL)
- Kaposi’s sarcoma
- multiple myeloma
- mycosis fungoides
- ovarian cancer
For the treatment of HIV-related Kaposi’s sarcoma in patients with disease that has progressed on prior combination chemotherapy or in patients who are intolerant to other therapy
Side Effects
- abdominal pain
- abdominal pain
- acne vulgaris
- alopecia
- anemia
- anemia
- anorexia
- anorexia
- apnea
- asthenia
- asthenia
- back pain
- back pain
- bronchospasm
- bullous rash
- bundle-branch block
- candidiasis
- cardiac arrest
- cardiomyopathy
- chest pain (unspecified)
- chills
- Co-Enzyme Q-10 deficiency
- conjunctivitis
- constipation
- constipation
- cough
- cyanosis
- dehydration
- depression
- diarrhea
- diarrhea
- dizziness
- drowsiness
- dysesthesia
- dysesthesia
- dysgeusia
- dyspepsia
- dyspepsia
- dysphagia
- dyspnea
- dyspnea
- ecchymosis
- elevated hepatic enzymes
- epistaxis
- erythema multiforme
- esophagitis
- exfoliative dermatitis
- fatigue
- fatigue
- fever
- fever
- flushing
- furunculosis
- GI bleeding
- headache
- headache
- heart failure
- hematuria
- hepatitis
- hyperbilirubinemia
- hypercalcemia
- hypokalemia
- hyponatremia
- hypotension
- ileus
- infection
- infection
- infusion-related reactions
- leukemia
- maculopapular rash
- muscle cramps
- nausea
- nausea
- neutropenia
- neutropenia
- new primary malignancy
- oral ulceration
- palmar-plantar erythrodysesthesia (hand and foot syndrome)
- palmar-plantar erythrodysesthesia (hand and foot syndrome)
- palpitations
- paresthesias
- paresthesias
- peripheral neuropathy
- peripheral neuropathy
- peripheral vasodilation
- pharyngitis
- phlebitis
- pruritus
- pulmonary embolism
- radiation recall reaction
- rash
- rash
- rhinitis
- sinus tachycardia
- sinusitis
- skin discoloration
- Stevens-Johnson syndrome
- stomatitis
- stomatitis
- syncope
- thrombocytopenia
- thrombocytopenia
- thrombosis
- toxic epidermal necrolysis
- vesicular rash
- vomiting
- vomiting
- weight loss
- xerophthalmia
- xerosis
Monitoring Parameters
- CBC with differential
- echocardiogram
- LFTs
- multi-gated radionuclide angiography (MUGA)
- pregnancy testing
Contraindications
- anthracycline hypersensitivity
- breast-feeding
- cardiac disease
- cardiomyopathy
- cardiotoxicity
- contraception requirements
- ensure correct formulation selection
- extravasation
- hepatic disease
- infertility
- infusion-related reactions
- male-mediated teratogenicity
- neutropenia
- new primary malignancy
- pregnancy
- pregnancy testing
- radiation therapy
- reproductive risk
- serious rash
- stomatitis
- thrombocytopenia
Interactions
- Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
- Amphotericin B
- Amphotericin B cholesteryl sulfate complex (ABCD)
- Amphotericin B lipid complex (ABLC)
- Amphotericin B liposomal (LAmB)
- Cenobamate
- Cyclophosphamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Digoxin
- Glecaprevir; Pibrentasvir
- Idelalisib
- Isavuconazonium
- Lamivudine, 3TC; Zidovudine, ZDV
- Lopinavir; Ritonavir
- Mercaptopurine, 6-MP
- Ombitasvir; Paritaprevir; Ritonavir
- Palifermin
- Penicillamine
- Ritonavir
- Streptozocin
- Tuberculin Purified Protein Derivative, PPD
- Zidovudine, ZDV
