How should colchicine be dosed in the treatment of gout?
- • Acute gout flare: 1.2 mg followed by 0.6 mg in 1 hour.
- Most effective if started in first few hours of gout attack.
- Similar efficacy to prior “high-dose” regimens used in the past.
- • Gout prophylaxis: 0.6 mg once or twice daily.
Colchicine has no effect on serum urate concentration or on urate metabolism and is inappropriate as monotherapy if patient has indication for ULT. Colchicine is available as 0.6-mg tablets in the United States and 0.5-mg tablets elsewhere in the world.
