Dosage equivalents of sedative hypnotics

Dosage equivalents of sedative hypnotics

What are the dosage equivalents of the commonly used sedative hypnotics? 

  • Here is the table which provides approximate equivalencies for commonly used sedative hypnotics.
  • It is important to note that there can be significant differences in metabolism of and sensitivity to these agents for each individual.

Sedative Hypnotic Dose Equivalents

Generic NameDose Equivalents (mg)
Benzodiazepines
Clonazepam0.25-0.5
Alprazolam0.5
Lorazepam1
Diazepam5
Chlordiazepoxide12
Barbiturates
Phenobarbitol30
Pentobarbitol100
  • Dosage equivalents of sedative-hypnotics, also known as sleep medications or tranquilizers, can vary depending on the specific medication and individual factors such as age, weight, and tolerance.
  • The following are approximate dosage equivalents of commonly used sedative-hypnotic medications:
  1. Benzodiazepines:
    • Diazepam (Valium): 5 mg = Alprazolam (Xanax): 0.25 mg = Lorazepam (Ativan): 1 mg
    • These are rough equivalences and can vary depending on the specific needs of the individual.
  2. Z-drugs (Non-benzodiazepine sedative-hypnotics):
    • Zolpidem (Ambien): 10 mg = Zopiclone (Imovane): 7.5 mg = Eszopiclone (Lunesta): 3 mg
    • Again, these are approximate equivalents, and individual responses can vary.
  • It’s important to note that dosage equivalents can differ based on various factors, including the intended use, individual tolerance, and specific patient considerations. The recommended dosage and duration of treatment should always be determined by a healthcare professional based on a thorough evaluation of the patient’s condition, medical history, and individual needs. Dosages should never be adjusted or changed without consulting a healthcare provider.
  • Additionally, sedative-hypnotics should only be used under the guidance and supervision of a healthcare professional, as they can have significant side effects and risks, including dependency, tolerance, and potential interactions with other medications. It’s important to follow prescribed dosages, use them as directed, and inform healthcare providers of any other medications or health conditions to ensure safe and appropriate use.

Sources

Adapted from Renner R Jr., Ward E. Drug addiction. In Stern TA, Fava M, Wilens TE, Rosenbaum JF, editors. Massachusetts General Hospital Comprehensive Clinical Psychiatry. London, Elsevier, p. 303. ( Table 27-3 ), 2016.

15585

Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

15856