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What is Diltiazem Enalapril
NOTE: This drug is discontinued in the US.
Enalapril, an angiotensin converting enzyme inhibitor, and diltiazem, a calcium-channel blocker may be prescribed together in an oral combination as a second-line treatment for hypertension.
The drugs have complimentary mechanisms of action which decrease peripheral resistance and lower blood pressure.
Each extended-release Teczem® tablet consists of a diltiazem core within a semipermeable membrane. The core is coated with enalapril, which is released immediately after tablet ingestion.
When the coating dissolves and water permeates the core membrane, diltiazem is dissolved and released.
Teczem® is a once daily dosage form for patients who fail on single-drug therapy with either enalapril or diltiazem, and require addition of another antihypertensive agent. The combination product produces significantly greater blood pressure reductions than either agent used alone.
Teczem® was approved in October 1996.
This drug was withdrawn from the market in 1999.
Indications
- hypertension
NOTE: This drug is discontinued in the US.
For the treatment of hypertension in patients who do not respond to monotherapy
Side Effects
- agranulocytosis
- alopecia
- anaphylactoid reactions
- angina
- angioedema
- anorexia
- aplastic anemia
- arthralgia
- asthenia
- atrial fibrillation
- AV block
- azotemia
- blurred vision
- bradycardia
- bronchospasm
- cholestasis
- confusion
- constipation
- cough
- depression
- diaphoresis
- diarrhea
- dizziness
- drowsiness
- dysgeusia
- dyspnea
- edema
- elevated hepatic enzymes
- erythema multiforme
- exfoliative dermatitis
- fatigue
- fever
- flushing
- gingival hyperplasia
- glomerulonephritis
- gynecomastia
- headache
- heart failure
- hemolytic anemia
- hepatic failure
- hepatic necrosis
- hepatitis
- hyperkalemia
- hypotension
- impotence (erectile dysfunction)
- insomnia
- jaundice
- maculopapular rash
- myalgia
- nausea
- neutropenia
- orthostatic hypotension
- palpitations
- pancytopenia
- pemphigus
- peripheral edema
- photosensitivity
- pneumonitis
- pruritus
- pulmonary edema
- renal tubular necrosis
- sinus tachycardia
- Stevens-Johnson syndrome
- syncope
- teratogenesis
- thrombocytopenia
- toxic epidermal necrolysis
- urticaria
- vomiting
Monitoring Parameters
- blood pressure
- heart rate
- serum creatinine/BUN
- serum potassium
- serum sodium
Contraindications
- ACE-inhibitor induced angioedema
- acute myocardial infarction
- Angiotensin-converting enzyme inhibitors (ACE inhibitors) hypersensitivity
- aortic stenosis
- autoimmune disease
- AV block
- Black patients
- bone marrow suppression
- bradycardia
- breast-feeding
- cardiogenic shock
- cardiomyopathy
- cerebrovascular disease
- children
- collagen-vascular disease
- coronary artery disease
- desensitization procedures
- dialysis
- dysphagia
- geriatric
- GI obstruction
- heart failure
- hepatic disease
- hereditary angioedema
- history of angioedema
- hyperkalemia
- hyponatremia
- hypotension
- hypovolemia
- immunosuppression
- low-density lipoprotein apheresis
- Lown-Ganong-Levine syndrome
- pregnancy
- pulmonary edema
- renal artery stenosis
- renal disease
- renal failure
- renal impairment
- sick sinus syndrome
- surgery
- ventricular dysfunction
- ventricular tachycardia
- Wolff-Parkinson-White syndrome
Interactions
No information is available regarding drug interactions associated with Diltiazem Enalapril
