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Desoximetasone Brand Names
Topicort | Topicort LP
What is Desoximetasone
Desoximetasone is a topical medium- to high-potency synthetic fluorinated corticosteroid.
It is used for the relief of moderate to severe inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses and for psoriasis.
Desoximetasone has anti-inflammatory, antipruritic, and vasoconstrictive properties. Medium- to high-potency topical corticosteroids can be useful for treatment of areas with thicker skin such as the palms and soles.
The FDA first approved desoximetasone for topical use in 1977.
Indications
- alopecia
- atopic dermatitis
- contact dermatitis
- discoid lupus erythematosus
- eczema
- exfoliative dermatitis
- granuloma annulare
- keloids
- lichen planus
- lichen simplex
- lichen striatus
- necrobiosis lipoidica diabeticorum
- pemphigus
- pityriasis rosea
- pruritus
- psoriasis
- Rhus dermatitis
- sarcoidosis
- seborrheic dermatitis
- urticaria
- xerosis
Side Effects
- acneiform rash
- adrenocortical insufficiency
- cataracts
- contact dermatitis
- Cushing’s syndrome
- erythema
- folliculitis
- glycosuria
- growth inhibition
- headache
- hyperglycemia
- hypertension
- hypertrichosis
- hypothalamic-pituitary-adrenal (HPA) suppression
- impaired wound healing
- increased intracranial pressure
- infection
- maculopapular rash
- miliaria
- ocular hypertension
- papilledema
- pruritus
- pseudotumor cerebri
- purpura
- skin atrophy
- skin hypopigmentation
- skin irritation
- skin ulcer
- striae
- telangiectasia
- tolerance
- visual impairment
- withdrawal
- xerosis
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- acne rosacea
- acne vulgaris
- breast-feeding
- cataracts
- children
- Cushing’s syndrome
- diabetes mellitus
- fungal infection
- geriatric
- glaucoma
- growth inhibition
- herpes infection
- hypothalamic-pituitary-adrenal (HPA) suppression
- increased intracranial pressure
- infants
- infection
- measles
- neonates
- occlusive dressing
- ocular exposure
- ophthalmic administration
- perioral dermatitis
- pregnancy
- skin abrasion
- skin atrophy
- tuberculosis
- varicella
- viral infection
Interactions
- Metyrapone
Metyrapone: (Major) Medications which affect pituitary or adrenocortical function, including all corticosteroid therapy, should be discontinued prior to and during testing with metyrapone.
Patients taking inadvertent doses of corticosteroids on the test day may exhibit abnormally high basal plasma cortisol levels and a decreased response to the test.
Although systemic absorption of topical corticosteroids is minimal, temporary discontinuation of these products should be considered if possible to reduce the potential for interference with the test results.
