Denileukin Diftitox Brand Name– Ontak
What is Denileukin Diftitox
Denileukin diftitox is a CD25-directed cytotoxin that is indicated for the treatment of persistent or recurrent cutaneous T-cell lymphoma in adult patients whose malignant cells express the CD25 component of the IL-2 receptor.
Fatal cases of capillary leak syndrome and infusion-related reactions have been reported with denileukin diftitox therapy.
Indications
- cutaneous T-cell lymphoma (CTCL)
- non-Hodgkin’s lymphoma (NHL)
- psoriasis
For treatment of cutaneous T-cell lymphoma (CTCL)
Side Effects
- anorexia
- antibody formation
- arthralgia
- asthenia
- back pain
- capillary leak syndrome
- chest pain (unspecified)
- chills
- cough
- diarrhea
- dizziness
- dysgeusia
- dyspnea
- elevated hepatic enzymes
- fatigue
- fever
- headache
- hyperthyroidism
- hypoalbuminemia
- hypotension
- hypothyroidism
- infection
- infusion-related reactions
- infusion-related reactions
- myalgia
- nausea
- peripheral edema
- pruritus
- rash
- thyrotoxicosis
- visual impairment
- vomiting
Monitoring Parameters
- blood pressure
- ophthalmologic exam
- pregnancy testing
- serum albumin
- weight
Contraindications
- breast-feeding
- capillary leak syndrome
- contraception requirements
- hypoalbuminemia
- infusion-related reactions
- pregnancy
- pregnancy testing
- requires a specialized care setting
- visual impairment
Interactions
- Abciximab
- Alteplase
- Anagrelide
- Anticoagulants
- Antithrombin III
- Antithymocyte Globulin
- Apixaban
- Argatroban
- Aspirin, ASA; Dipyridamole
- Azelastine; Fluticasone
- Beclomethasone
- Betamethasone
- Betrixaban
- Bivalirudin
- Budesonide
- Budesonide; Formoterol
- Ciclesonide
- Cilostazol
- Clopidogrel
- Clozapine
- Corticosteroids
- Corticotropin, ACTH
- Cortisone
- Dabigatran
- Dalteparin
- Danaparoid
- Deflazacort
- Desirudin
- Dexamethasone
- Diclofenac
- Diclofenac; Misoprostol
- Digoxin
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Dipyridamole
- Echinacea
- Edoxaban
- Enoxaparin
- Eptifibatide
- Esomeprazole; Naproxen
- Etodolac
- Famotidine; Ibuprofen
- Fenoprofen
- Filgrastim, G-CSF
- Fludrocortisone
- Flunisolide
- Flurbiprofen
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fondaparinux
- Formoterol; Mometasone
- Heparin
- Hydrocodone; Ibuprofen
- Hydrocortisone
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Indomethacin
- Ketoprofen
- Ketorolac
- Lansoprazole; Naproxen
- Lepirudin
- Meclofenamate Sodium
- Mefenamic Acid
- Meloxicam
- Methylprednisolone
- Mometasone
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Oxaprozin
- Palifermin
- Pegfilgrastim
- Penicillamine
- Pentosan
- Piroxicam
- Platelet Inhibitors
- Prasugrel
- Prednisolone
- Prednisone
- Reteplase, r-PA
- Rivaroxaban
- Rofecoxib
- Streptokinase
- Sulindac
- Tbo-Filgrastim
- Tenecteplase
- Thrombolytic Agents
- Ticagrelor
- Ticlopidine
- Tinzaparin
- Tirofiban
- Tolmetin
- Triamcinolone
- Tuberculin Purified Protein Derivative, PPD
- Urokinase
- Vinblastine
- Vorapaxar
- Warfarin
