Danaparoid Brand Name– Orgaran
What is Danaparoid
Danaparoid is a heparinoid representing a mixture of low-molecular weight sulfated glycosaminoglycans: heparan (not heparin) sulfate (84%), dermatan sulfate (12%), and chondroitin sulfate (4%).
Danaparoid is obtained from porcine intestinal mucosa after the removal of heparin.
The mean molecular weight of danaparoid is 5500 daltons.
Only a small subfraction (4%) of heparan sulfate contains the pentasaccharide sequence common to unfractionated heparin (UFH) and low-molecular weight heparins (LMWHs).
Because danaparoid has a low rate of in vitro cross-reactivity (mean 9%) with heparin-induced antibodies, the risk of type II (immune-mediated) thrombocytopenia is much less than with UFH or LMWHs.
Danaparoid has been compared with UFH or warfarin for several clinical indications, including deep venous thrombosis (DVT) prophylaxis, DVT treatment, and heparin-induced thrombocytopenia.
It is at least as effective as warfarin for prevention of DVT in patients undergoing hip replacement surgery.
Danaparoid was approved for prophylaxis of post-operative DVT, which may lead to pulmonary embolism, in patients undergoing elective hip replacement surgery on 12/23/96.
Indications
- deep venous thrombosis (DVT)
- deep venous thrombosis (DVT) prophylaxis
- heparin-induced thrombocytopenia
- thrombosis prophylaxis
For the treatment of deep venous thrombosis (DVT)
Side Effects
- anaphylactoid reactions
- bleeding
- constipation
- fever
- GI bleeding
- hematoma
- hematuria
- injection site reaction
- maculopapular rash
- nausea
- thrombocytopenia
- vomiting
Monitoring Parameters
- anti-Xa activity
- hemoglobin/hematocrit
- platelet count
- prothrombin time (PT)
- serum creatinine
- stool guaiac
- urinalysis
Contraindications
- aneurysm
- anticoagulant therapy
- bleeding
- breast-feeding
- children
- coagulopathy
- diabetic retinopathy
- diverticulitis
- endocarditis
- epidural anesthesia
- GI bleeding
- hemophilia
- hepatic disease
- hypertension
- immune thrombocytopenic purpura (ITP)
- inflammatory bowel disease
- intramuscular injections
- lumbar puncture
- menstruation
- peptic ulcer disease
- porcine protein hypersensitivity
- pregnancy
- renal failure
- renal impairment
- spinal anesthesia
- stroke
- sulfite hypersensitivity
- surgery
- thrombocytopenia
- thrombolytic therapy
- ulcerative colitis
Interactions
- Abciximab
- Ado-Trastuzumab emtansine
- Alteplase
- Altretamine
- Amlodipine; Celecoxib
- Anagrelide
- Antithrombin III
- Antithymocyte Globulin
- Arsenic Trioxide
- Aspirin, ASA; Dipyridamole
- Caplacizumab
- Carbenicillin
- Celecoxib
- Chlorambucil
- Cilostazol
- Clofarabine
- Clopidogrel
- Collagenase
- Cytarabine, ARA-C
- Dabigatran
- Dalteparin
- Danazol
- Dasatinib
- Decitabine
- Deferasirox
- Defibrotide
- Denileukin Diftitox
- Desirudin
- Dextran
- Diclofenac
- Diclofenac; Misoprostol
- Diflunisal
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Dipyridamole
- Drotrecogin Alfa
- Eltrombopag
- Enoxaparin
- Epoprostenol
- Eptifibatide
- Esomeprazole; Naproxen
- Esterified Estrogens; Methyltestosterone
- Estramustine
- Etodolac
- Famotidine; Ibuprofen
- Fenoprofen
- Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
- Floxuridine
- Fluorouracil, 5-FU
- Flurbiprofen
- Folate analogs
- Fondaparinux
- Garlic, Allium sativum
- Ginger, Zingiber officinale
- Ginkgo, Ginkgo biloba
- Green Tea
- Hemin
- Heparin
- Hydrocodone; Ibuprofen
- Hydroxyurea
- Ibritumomab Tiuxetan
- Ibrutinib
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Icosapent ethyl
- Iloprost
- Imatinib
- Indomethacin
- Inotersen
- Interferon Alfa-2a
- Interferon Alfa-2b
- Interferon Alfa-2b; Ribavirin
- Interferon Alfa-n3
- Interferon Alfacon-1
- Intravenous Lipid Emulsions
- Ketoprofen
- Ketorolac
- Lansoprazole; Naproxen
- Lomustine, CCNU
- Meclofenamate Sodium
- Mefenamic Acid
- Meloxicam
- Methoxsalen
- Methylsulfonylmethane, MSM
- Methyltestosterone
- Miltefosine
- Mycophenolate
- Nabumetone
- Nandrolone Decanoate
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Natural Antineoplastics
- Nelarabine
- Nintedanib
- Nonsteroidal antiinflammatory drugs
- Obinutuzumab
- Omacetaxine
- Oxandrolone
- Oxaprozin
- Pentosan
- Piperacillin
- Piperacillin; Tazobactam
- Piroxicam
- Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
- Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
- Prasugrel
- Reteplase, r-PA
- Rivaroxaban
- Rofecoxib
- Selective serotonin reuptake inhibitors
- Serotonin norepinephrine reuptake inhibitors
- Sodium Hyaluronate, Hyaluronic Acid
- Sodium Iodide
- Streptokinase
- Sulfinpyrazone
- Sulindac
- Telavancin
- Tenecteplase
- Thrombolytic Agents
- Ticagrelor
- Ticarcillin
- Ticarcillin; Clavulanic Acid
- Ticlopidine
- Tinzaparin
- Tipranavir
- Tirofiban
- Tolmetin
- Trazodone
- Treprostinil
- Tretinoin, ATRA
- Urokinase
- Valdecoxib
- Verteporfin
- Vilazodone
- Vorapaxar
- Vorinostat
- Vortioxetine
- Warfarin
