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Carbachol Brand Names
Carbastat | Isopto Carbachol | Miostat
What is Carbachol
Carbachol is a direct-acting ophthalmic miotic agent.
Although carbachol is used exclusively as an ophthalmic preparation and extensive systemic absorption is not expected, systemic cholinergic side effects have been reported.
Therefore, careful monitoring is advisable in some patient populations. This drug was approved by the FDA in 1972.
Marketed products include carbachol ophthalmic solution (Isopto Carbachol) for lowering intraocular pressure in the treatment of glaucoma, and carbachol solution for intraocular injection (Miostat) for use as a miotic agent during surgery, and to decrease intraocular pressure following cataract surgery.
Indications
- glaucoma
- increased intraocular pressure
- miosis induction
For intraocular miosis induction during surgery and to reduce increased intraocular pressure during the first 24 hours after cataract surgery
Side Effects
- abdominal pain
- blurred vision
- bronchospasm
- ciliary body spasm
- conjunctival hyperemia
- corneal edema
- corneal opacification
- diarrhea
- flushing
- headache
- hyperhidrosis
- hypersalivation
- hypotension
- iritis
- keratopathy
- miosis
- night blindness
- ocular inflammation
- ocular irritation
- ocular pain
- retinal detachment
- sinus tachycardia
- syncope
- urinary retention
- urinary urgency
- visual impairment
- vomiting
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- acute heart failure
- asthma
- breast-feeding
- cardiac disease
- children
- contact lenses
- corneal abrasion
- driving or operating machinery
- hypertension
- hyperthyroidism
- hypotension
- infants
- iritis
- latex hypersensitivity
- myocardial infarction
- neonates
- Parkinson’s disease
- peptic ulcer disease
- pregnancy
- retinal detachment
- urinary tract obstruction
Interactions
There are no drug interactions associated with Carbachol products.
