Brimonidine Brinzolamide Brand Name– SIMBRINZA
What is Brimonidine Brinzolamide
Brimonidine brinzolamide is available as fixed-dose ophthalmic drop that is administered as 1 drop three times daily, with the intent of reducing medication burden.
Brimonidine, a selective alpha-agonist, and brinzolamide, a carbonic anhydrase inhibitor, are combined together to decrease intraocular pressure (IOP) in patients with ocular hypertension or open-angle glaucoma.
The fixed dose combination resulted in a statistically significantly greater reduction in IOP (16.3—19.8 mm Hg) after 3 months of treatment than that of either brimonidine 0.2% (17.9—22.5 mm Hg; p < 0.001) or brinzolamide 1% (19.3—20.9 mm Hg; p < 0.002) administered as monotherapy in a clinical trial of 660 patients with either open-angle glaucoma or ocular hypertension.
Brimonidine brinzolamide (Simbrinza) was FDA-approved in April 2013.
Indications
- glaucoma
- ocular hypertension
For the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension
Side Effects
- alopecia
- anxiety
- arrhythmia exacerbation
- asthenia
- blepharedema
- blepharitis
- blurred vision
- bradycardia
- chest pain (unspecified)
- conjunctival hyperemia
- conjunctivitis
- contact dermatitis
- corneal edema
- corneal erosion
- depression
- diarrhea
- diplopia
- dizziness
- drowsiness
- dysgeusia
- dyspepsia
- dyspnea
- edema
- erythema
- fatigue
- foreign body sensation
- headache
- hypertension
- hypertonia
- insomnia
- iritis
- keratitis
- keratoconjunctivitis
- keratopathy
- miosis
- musculoskeletal pain
- nasal dryness
- nausea
- ocular discharge
- ocular hemorrhage
- ocular irritation
- ocular pain
- ocular pruritus
- palpitations
- pharyngitis
- photophobia
- rhinitis
- sinus tachycardia
- syncope
- urticaria
- visual impairment
- xerophthalmia
- xerostomia
Monitoring Parameters
- intraocular pressure
Contraindications
- breast-feeding
- cardiac disease
- children
- closed-angle glaucoma
- contact lenses
- depression
- hepatic disease
- infants
- neonates
- orthostatic hypotension
- pregnancy
- Raynaud’s phenomenon
- renal impairment
- sulfonamide hypersensitivity
- thromboangiitis obliterans (Buerger’s disease)
Interactions
- Alprazolam
- Amitriptyline; Chlordiazepoxide
- Anxiolytics; Sedatives; and Hypnotics
- Barbiturates
- Benzodiazepines
- Cardiac glycosides
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Clonazepam
- Clorazepate
- Diazepam
- Estazolam
- Ethanol
- Flurazepam
- Linezolid
- Lorazepam
- Mepenzolate
- Midazolam
- Monoamine oxidase inhibitors
- Opiate Agonists
- Oxazepam
- Quazepam
- Rasagiline
- Temazepam
- Triazolam
- Tricyclic antidepressants
