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Bimatoprost Brand Names
DURYSTA | Latisse | Lumigan
What is Bimatoprost
Bimatoprost is a synthetic structural analog of prostaglandin indicated for the reduction of intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension.
The drug lowers IOP by increasing the outflow of aqueous humor through both the trabecular meshwork and uveoscleral routes.
Bimatoprost is also approved for the treatment of hypotrichosis of the eyelashes. In patients with hypotrichosis, bimatoprost increased eyelash prominence, length, fullness or thickness, and darkness after 8, 12, and 16 weeks of use.
The drug is commercially available as an ophthalmic solution (0.1% and 0.3%) and as a 10 mcg intracameral implant; the intracameral implant must be inserted by a health care professional under standard aseptic conditions.
As with latanoprost and travoprost, bimatoprost has been associated with changes to pigmented tissues including increased pigmentation of eyelashes, the iris, and periorbital tissue.
Changes in iridal pigmentation may be permanent.
Indications
- glaucoma
- hypotrichosis
- increased intraocular pressure
- ocular hypertension
For the reduction of elevated or increased intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension
Side Effects
- asthenia
- blepharitis
- blurred vision
- cataracts
- conjunctival hyperemia
- conjunctivitis
- corneal degeneration
- corneal edema
- corneal erosion
- corneal opacification
- dizziness
- dyspnea
- erythema
- foreign body sensation
- headache
- hirsutism
- hypertension
- hypertrichosis
- hyphema
- infection
- iridal discoloration
- iritis
- keratitis
- lacrimation
- macular edema
- maculopapular rash
- nausea
- ocular discharge
- ocular hemorrhage
- ocular hypertension
- ocular inflammation
- ocular irritation
- ocular pain
- ocular pruritus
- photophobia
- skin hyperpigmentation
- uveitis
- visual impairment
- xerophthalmia
Monitoring Parameters
- intraocular pressure
- ophthalmologic exam
Contraindications
- aphakia
- breast-feeding
- children
- closed-angle glaucoma
- contact lenses
- corneal abrasion
- corneal transplant
- infants
- iritis
- keratitis
- neonates
- ocular infection
- ocular surgery
- ocular trauma
- pregnancy
- sunlight (UV) exposure
- uveitis
Interactions
There are no drug interactions associated with Bimatoprost products.
