Betamethasone Clotrimazole Brand Name– Lotrisone
What is Betamethasone Clotrimazole
Betamethasone and clotrimazole are used together in a topical preparation, Lotrisone, to treat patients >= 17 years of age with tinea pedis, tinea cruris, and tinea corporis infections caused by Epidermophyton floccosum, Trichophyton mentagrophytes, and Trichophyton rubrum.
Lotrisone contains betamethasone dipropionate 0.05%, which is considered a high potency corticosteroid with antiinflammatory, vasoconstrictive, and antipruritic properties, and clotrimazole which is an imidazole antifungal agent.
Approval was based on the results of clinical trials in which patients infected with tinea corporis, tinea cruris, and tinea pedis achieved better clinical response at the first return visit than patients treated with clotrimazole cream; mycological cure rates with Lotrisone were as good as, or better than, clotrimazole cream.
Lotrisone was approved by the FDA in July 1984.
Indications
- Candida albicans
- Candida sp.
- candidiasis
- Epidermophyton floccosum
- Microsporum canis
- tinea corporis
- tinea cruris
- tinea pedis
- Trichophyton mentagrophytes
- Trichophyton rubrum
Side Effects
- acneiform rash
- blurred vision
- cataracts
- contact dermatitis
- Cushing’s syndrome
- edema
- erythema
- folliculitis
- growth inhibition
- headache
- hyperglycemia
- hypertrichosis
- hypothalamic-pituitary-adrenal (HPA) suppression
- increased intracranial pressure
- infection
- miliaria
- ocular hypertension
- papilledema
- paresthesias
- pruritus
- rash
- retinopathy
- skin atrophy
- skin hypopigmentation
- skin irritation
- striae
- xerosis
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- azole antifungals hypersensitivity
- breast-feeding
- cataracts
- children
- geriatric
- glaucoma
- growth inhibition
- increased intracranial pressure
- infants
- neonates
- ocular exposure
- peripheral vascular disease
- pregnancy
- skin abrasion
- skin atrophy
Interactions
- Progesterone
