Basiliximab

Basiliximab Brand Name– Simulect

What is Basiliximab

Basiliximab is an immunosuppressant used to prevent rejection in renal allograft recipients. Like daclizumab, basiliximab is a recombinant, chimeric (murine/human) monoclonal antibody (IgG1) against CD25, the interleukin-2 receptor alpha-chain.

When used prophylactically in combination with cyclosporine and corticosteroids, basiliximab reduces biopsy-confirmed rejection episodes in patients undergoing renal transplantation.

The reduction in acute rejection achieved with basiliximab is similar to that observed with daclizumab.

In contrast to less specific immunosuppressants such as cyclosporine, the adverse event profile of basiliximab is comparable to that of placebo. Other potential benefits of basiliximab therapy include lack of myelosuppression and no increased risk of lymphoma or other malignancies.

The FDA granted final approval of basiliximab for prevention of renal allograft rejection in May 1998.

Basiliximab has also been studied in the prevention of liver transplant rejection.

Indications

  • kidney transplant rejection prophylaxis
  • liver transplant rejection prophylaxis

For acute kidney transplant rejection prophylaxis when used as part of an immunosuppressive regimen that includes cyclosporine and corticosteroids

Side Effects

  1. abdominal pain
  2. acne vulgaris
  3. agitation
  4. anaphylactoid reactions
  5. anemia
  6. angina
  7. antibody formation
  8. anxiety
  9. arthralgia
  10. arthropathy
  11. asthenia
  12. atrial fibrillation
  13. back pain
  14. bleeding
  15. bone fractures
  16. bronchospasm
  17. cardiac arrest
  18. cataracts
  19. chest pain (unspecified)
  20. chills
  21. conjunctivitis
  22. constipation
  23. cough
  24. dehydration
  25. depression
  26. diabetes mellitus
  27. diarrhea
  28. dizziness
  29. dyspepsia
  30. dyspnea
  31. dysuria
  32. edema
  33. esophagitis
  34. fatigue
  35. fever
  36. flatulence
  37. fluid retention
  38. GI bleeding
  39. gingival hyperplasia
  40. headache
  41. heart failure
  42. hematoma
  43. hematuria
  44. hypercalcemia
  45. hypercholesterolemia
  46. hyperglycemia
  47. hyperkalemia
  48. hyperlipidemia
  49. hypertension
  50. hypertrichosis
  51. hypertriglyceridemia
  52. hyperuricemia
  53. hypocalcemia
  54. hypoesthesia
  55. hypoglycemia
  56. hypokalemia
  57. hypomagnesemia
  58. hypophosphatemia
  59. hypotension
  60. impotence (erectile dysfunction)
  61. increased urinary frequency
  62. infection
  63. injection site reaction
  64. insomnia
  65. leukopenia
  66. malaise
  67. melena
  68. metabolic acidosis
  69. muscle cramps
  70. myalgia
  71. nausea
  72. oliguria
  73. paresthesias
  74. peripheral edema
  75. peripheral neuropathy
  76. pharyngitis
  77. polycythemia
  78. post-transplant lymphoproliferative disorder (PTLD)
  79. proteinuria
  80. pruritus
  81. pulmonary edema
  82. purpura
  83. rash
  84. renal tubular necrosis
  85. respiratory arrest
  86. rhinitis
  87. sinus tachycardia
  88. sinusitis
  89. skin ulcer
  90. stomatitis
  91. thrombocytopenia
  92. thrombosis
  93. tremor
  94. urinary retention
  95. urticaria
  96. visual impairment
  97. vomiting
  98. weight gain
  99. wheezing

Monitoring Parameters

  • CBC

Contraindications

  • breast-feeding
  • children
  • fungal infection
  • herpes infection
  • human anti-murine antibody (HAMA)
  • infection
  • lymphoma
  • mannitol hypersensitivity
  • murine protein hypersensitivity
  • neoplastic disease
  • pregnancy
  • requires a specialized care setting
  • requires an experienced clinician
  • vaccination
  • varicella
  • viral infection

Interactions

  • Abatacept
  • Alefacept
  • Alpha interferons
  • Antithymocyte Globulin
  • Azathioprine
  • Certolizumab pegol
  • Cladribine
  • Corticosteroids
  • Cyclophosphamide
  • Cyclosporine
  • Daclizumab
  • Dichlorphenamide
  • Echinacea
  • Elbasvir; Grazoprevir
  • Fludarabine
  • Golimumab
  • Interferon Alfa-2a
  • Interferon Alfa-2b
  • Interferon Alfa-2b; Ribavirin
  • Interferon Alfa-n3
  • Interferon Alfacon-1
  • Live Vaccines
  • Mercaptopurine, 6-MP
  • Methotrexate
  • Mycophenolate
  • Natalizumab
  • Peginterferon Alfa-2a
  • Peginterferon Alfa-2b
  • Penicillamine
  • Pentostatin
  • Purine analogs
  • Rilonacept
  • Saquinavir
  • Sipuleucel-T
  • Sirolimus
  • Sofosbuvir; Velpatasvir
  • Sofosbuvir; Velpatasvir; Voxilaprevir
  • Tacrolimus
  • Thioguanine, 6-TG
  • Tocilizumab
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