Ardeparin Brand Name– Normiflo
What is Ardeparin
NOTE: This drug is discontinued in the US.
Ardeparin is a low molecular weight heparin produced through partial depolymerization of porcine mucosal heparin.
Like unfractionated heparin (UFH), ardeparin is a glycosaminoglycan that consists of chains of alternating residues of D-glucosamine and iduronic acid or glucuronic acid (i.e., hexuronic acid). Although it has the same molecular subunits as unfractionated heparin (UFH), ardeparin has smaller polymer chains.
Ardeparin contains fragments of 5650—6350 daltons, while UFH contains small and large polymer chains with molecular weights between 3,000—30,000 daltons.
Ardeparin producse a more predictable anticoagulant response than UFH, reflecting their better bioavailability after subcutaneous injection, longer half-life, and dose-independent clearance.
Ardeparin is used for the prevention of DVT in patients undergoing knee replacement surgery. It was the third low-molecular weight heparin to be approved in the United States.
Final FDA approval was granted May 23, 1997.
The manufacturer, Wyeth-Ayerst, has discontinued the ardeparin product Normiflo® in the US.
Indications
- deep venous thrombosis (DVT) prophylaxis
For the prevention of deep vein thrombosis (i.e., deep venous thrombosis (DVT) prophylaxis), which may lead to pulmonary embolism, following knee replacement surgery
Side Effects
- anemia
- arthralgia
- bleeding
- bullous rash
- chest pain (unspecified)
- confusion
- constipation
- dizziness
- dyspnea
- ecchymosis
- elevated hepatic enzymes
- epistaxis
- fever
- GI bleeding
- headache
- hematemesis
- hematoma
- hematuria
- hypertriglyceridemia
- injection site reaction
- insomnia
- intracranial bleeding
- maculopapular rash
- nausea
- ocular hemorrhage
- osteopenia
- osteoporosis
- peripheral edema
- petechiae
- pruritus
- retroperitoneal bleeding
- stroke
- thrombocytopenia
- urticaria
- vesicular rash
- vomiting
Monitoring Parameters
- anti-Xa activity
- hemoglobin/hematocrit
- platelet count
- prothrombin time (PT)
- serum creatinine
- stool guaiac
- urinalysis
Contraindications
- aneurysm
- anticoagulant therapy
- asthma
- bleeding
- breast-feeding
- children
- coagulopathy
- dental disease
- dental work
- diabetic retinopathy
- diverticulitis
- endocarditis
- epidural anesthesia
- GI bleeding
- hemophilia
- heparin hypersensitivity
- heparin-induced thrombocytopenia (HIT)
- hepatic disease
- hypertension
- immune thrombocytopenic purpura (ITP)
- inflammatory bowel disease
- intramuscular injections
- lumbar puncture
- menstruation
- paraben hypersensitivity
- peptic ulcer disease
- porcine protein hypersensitivity
- pregnancy
- renal failure
- renal impairment
- spinal anesthesia
- stroke
- sulfite hypersensitivity
- surgery
- thrombocytopenia
- thrombolytic therapy
- ulcerative colitis
Interactions
- Antithrombin III
- Apixaban
- Edoxaban
- Hydrochlorothiazide, HCTZ; Spironolactone
- Mifepristone
- Palifermin
- Phentermine; Topiramate
- Salicylates
- Selective serotonin reuptake inhibitors
- Sodium Hyaluronate, Hyaluronic Acid
- Spironolactone
- Telavancin
- Tipranavir
- Topiramate
- Vorapaxar
- Vorinostat
