Alectinib Brand Name– Alecensa
What is Alectinib
Alectinib is a tyrosine kinase inhibitor that targets ALK and RET. It is used for the treatment of patients with ALK-positive, metastatic non-small cell lung cancer (NSCLC).
Common adverse effects include fatigue, constipation, edema, myalgia, and anemia; serious adverse reactions include hepatotoxicity, pneumonitis, bradycardia, and elevated creatine phosphokinase (CPK).
Indications
- non-small cell lung cancer (NSCLC)
For the treatment of metastatic, ALK-positive non-small cell lung cancer (NSCLC)
Side Effects
- acneiform rash
- anemia
- anemia
- asthenia
- asthenia
- back pain
- bleeding
- blurred vision
- bradycardia
- constipation
- cough
- diarrhea
- diarrhea
- diplopia
- dysgeusia
- dysgeusia
- dyspnea
- dyspnea
- edema
- edema
- elevated hepatic enzymes
- elevated hepatic enzymes
- erythema
- exfoliative dermatitis
- fatigue
- fatigue
- GI perforation
- headache
- headache
- hyperbilirubinemia
- hyperbilirubinemia
- hyperglycemia
- hyperglycemia
- hyperkalemia
- hyperkalemia
- hypoalbuminemia
- hypocalcemia
- hypocalcemia
- hypokalemia
- hypokalemia
- hyponatremia
- hyponatremia
- hypophosphatemia
- hypophosphatemia
- infection
- lymphopenia
- lymphopenia
- maculopapular rash
- musculoskeletal pain
- musculoskeletal pain
- myalgia
- myalgia
- nausea
- nausea
- neutropenia
- peripheral edema
- photosensitivity
- pneumonitis
- pruritus
- pulmonary embolism
- QT prolongation
- rash
- rash
- renal failure (unspecified)
- stomatitis
- visual impairment
- vomiting
- vomiting
- weight gain
- weight gain
Monitoring Parameters
- creatine phosphokinase (CPK)
- LFTs
Contraindications
- AV block
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- contraception requirements
- hepatic disease
- hepatotoxicity
- hypotension
- male-mediated teratogenicity
- myopathy
- pneumonitis
- pregnancy
- pulmonary disease
- QT prolongation
- renal disease
- renal impairment
- reproductive risk
- rhabdomyolysis
- sick sinus syndrome
- sunlight (UV) exposure
- syncope
Interactions
- Porfimer
- Verteporfin
