Adefovir Brand Name– Hepsera
What is Adefovir
Adefovir dipivoxil is an acyclic nucleotide analog approved for the treatment of chronic hepatitis B virus (HBV) infections in patients 12 years and older.
The drug is administered once daily; however, the dosing interval must be expanded for patients with renal impairment.
Monitor renal function for all patients during treatment, as nephrotoxicity is treatment-limiting toxicity of adefovir.
In addition, the product labeling contains the following Black Box Warnings: nephrotoxicity; severe acute exacerbations of hepatitis; HIV resistance; lactic acidosis and severe hepatomegaly with steatosis.
Indications
- hepatitis B infection
- hepatitis B virus
Side Effects
- abdominal pain
- antimicrobial resistance
- asthenia
- azotemia
- bone fractures
- bone pain
- diarrhea
- dyspepsia
- elevated hepatic enzymes
- Fanconi syndrome
- flatulence
- headache
- hepatitis B exacerbation
- hepatomegaly
- hepatotoxicity
- hypophosphatemia
- lactic acidosis
- myopathy
- nausea
- nephrotoxicity
- osteomalacia
- pancreatitis
- pruritus
- rash
- renal failure (unspecified)
- steatosis
- vomiting
Monitoring Parameters
- hepatitis B serology
- LFTs
- serum creatinine/BUN
Contraindications
- breast-feeding
- children
- dialysis
- females
- geriatric
- hepatic disease
- hepatitis B and HIV coinfection
- hepatitis B exacerbation
- hepatotoxicity or lactic acidosis
- human immunodeficiency virus (HIV) infection
- human immunodeficiency virus (HIV) infection resistance
- infants
- liver transplant
- neonates
- nephrotoxicity
- obesity
- pregnancy
- renal disease
- renal failure
- renal impairment
Interactions
- Abacavir
- Abacavir; Dolutegravir; Lamivudine
- Abacavir; Lamivudine, 3TC
- Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
- Acyclovir
- Alogliptin; Metformin
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminoglycosides
- Amlodipine; Celecoxib
- Bictegravir; Emtricitabine; Tenofovir Alafenamide
- Cabozantinib
- Canagliflozin; Metformin
- Celecoxib
- Cidofovir
- Cimetidine
- Cisplatin
- Clofarabine
- Cyclosporine
- Dapagliflozin; Metformin
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dextromethorphan; Quinidine
- Dichlorphenamide
- Diclofenac
- Diclofenac; Misoprostol
- Didanosine, ddI
- Diflunisal
- Digoxin
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Dofetilide
- Dolutegravir; Lamivudine
- Dolutegravir; Rilpivirine
- Donepezil; Memantine
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Emtricitabine
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Emtricitabine; Tenofovir alafenamide
- Emtricitabine; Tenofovir disoproxil fumarate
- Entecavir
- Ertugliflozin; Metformin
- Esomeprazole; Naproxen
- Etodolac
- Famotidine; Ibuprofen
- Fenoprofen
- Flurbiprofen
- food
- Gallium Ga 68 Dotatate
- Glipizide; Metformin
- Glyburide; Metformin
- Hyaluronidase, Recombinant; Immune Globulin
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrocodone; Ibuprofen
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Immune Globulin IV, IVIG, IGIV
- Indomethacin
- Inotersen
- Ketoprofen
- Ketorolac
- Lamivudine, 3TC
- Lamivudine, 3TC; Zidovudine, ZDV
- Lamivudine; Tenofovir Disoproxil Fumarate
- Lansoprazole; Naproxen
- Linagliptin; Metformin
- Mannitol
- Maraviroc
- Meclofenamate Sodium
- Mefenamic Acid
- Meloxicam
- Memantine
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Midodrine
- Morphine
- Morphine; Naltrexone
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nitisinone
- Non-nucleoside reverse transcriptase inhibitors
- Nonsteroidal antiinflammatory drugs
- Oxaprozin
- Piroxicam
- Procainamide
- Protease inhibitors
- Quinidine
- Quinine
- Ranitidine
- Rilpivirine
- Rofecoxib
- Stavudine, d4T
- Sulindac
- Tacrolimus
- Telavancin
- Telbivudine
- Tenofovir Alafenamide
- Tenofovir, PMPA
- Tolmetin
- Triamterene
- Trospium
- Valacyclovir
- Valdecoxib
- Vancomycin
- Zalcitabine, ddC
- Zidovudine, ZDV
