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Adalimumab Brand Names
AMJEVITA | CYLTEZO | Humira
What is Adalimumab
Adalimumab is a subcutaneous monoclonal antibody specific for tumor necrosis factor-alpha (TNF-alpha), also known as a TNF-blocker.
Like other TNF-blockers, adalimumab is useful in a variety of inflammatory disorders, including dermatologic, arthritic, gastrointestinal, and ophthalmic inflammatory diseases.
In adults with rheumatoid arthritis (RA) or psoriatic arthritis (PsA) adalimumab products improve clinical signs and symptoms, inhibit the radiographic progression of structural joint damage, and improve physical function; in adults with ankylosing spondylitis (AS), adalimumab products improve clinical signs and symptoms of active disease, which can improve quality of life.
Indications
- ankylosing spondylitis
- Crohn’s disease
- hidradenitis suppurativa
- polyarticular juvenile idiopathic arthritis
- psoriasis
- psoriatic arthritis
- rheumatoid arthritis
- ulcerative colitis
- uveitis
For the treatment of moderately to severely active rheumatoid arthritis to reduce signs and symptoms of the disease, to induce a major clinical response, to inhibit the progression of structural damage, and to improve physical function
Side Effects
- abdominal pain
- agranulocytosis
- alopecia
- anaphylactic shock
- anaphylactoid reactions
- angioedema
- antibody formation
- aplastic anemia
- arrhythmia exacerbation
- arthralgia
- atrial fibrillation
- back pain
- bleeding
- bone fractures
- bronchospasm
- cardiac arrest
- cataracts
- chest pain (unspecified)
- cholecystitis
- cholelithiasis
- confusion
- cystitis
- dehydration
- dyspnea
- elevated hepatic enzymes
- encephalopathy
- erythema
- erythema multiforme
- esophagitis
- fever
- GI bleeding
- GI perforation
- Guillain-Barre syndrome
- headache
- heart failure
- hematuria
- hepatic failure
- hepatic necrosis
- hepatitis B exacerbation
- hypercholesterolemia
- hyperlipidemia
- hypertension
- impaired wound healing
- infection
- influenza
- injection site reaction
- leukopenia
- lichen planus-like eruption
- lupus-like symptoms
- lymphoma
- menstrual irregularity
- muscle cramps
- myasthenia
- myocardial infarction
- nausea
- nephrotic syndrome
- neutropenia
- new primary malignancy
- osteonecrosis
- palpitations
- pancreatitis
- pancytopenia
- paresthesias
- pelvic pain
- pericardial effusion
- pericarditis
- peripheral edema
- pharyngitis
- pleural effusion
- polycythemia
- proteinuria
- pruritus
- psoriaform rash
- psoriasis
- pulmonary embolism
- pulmonary fibrosis
- rash
- sinus tachycardia
- sinusitis
- Stevens-Johnson syndrome
- stroke
- subdural hematoma
- syncope
- synovitis
- thrombocytopenia
- thrombosis
- tremor
- urticaria
- vasculitis
- vomiting
Monitoring Parameters
- hepatitis B serology
- tuberculin skin test
Contraindications
- bone marrow suppression
- breast-feeding
- children
- cholangitis
- chronic obstructive pulmonary disease (COPD)
- corticosteroid therapy
- diabetes mellitus
- fungal infection
- geriatric
- Guillain-Barre syndrome
- heart failure
- hepatitis
- hepatitis B exacerbation
- history of angioedema
- immunosuppression
- infants
- infection
- inflammatory bowel disease
- latex hypersensitivity
- multiple sclerosis
- mycobacterial infection
- neonates
- neurological disease
- new primary malignancy
- optic neuritis
- positive antinuclear antibodies
- pregnancy
- sepsis
- serious hypersensitivity reactions or anaphylaxis
- surgery
- tuberculosis
- vaccination
- viral infection
Interactions
- Abatacept
- Anakinra
- Antithymocyte Globulin
- Azathioprine
- Azelastine; Fluticasone
- Baricitinib
- Beclomethasone
- Belimumab
- Betamethasone
- Budesonide
- Budesonide; Formoterol
- Canakinumab
- Certolizumab pegol
- Ciclesonide
- Corticosteroids
- Corticotropin, ACTH
- Cortisone
- Cyclophosphamide
- Cyclosporine
- Deflazacort
- Dexamethasone
- Etanercept
- Fludrocortisone
- Flunisolide
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Formoterol; Mometasone
- Golimumab
- Hydrocortisone
- Infliximab
- Live Vaccines
- Methotrexate
- Methylprednisolone
- Mometasone
- Muromonab-CD3
- Natalizumab
- Prednisolone
- Prednisone
- Rabies Vaccine
- Rilonacept
- Rituximab
- Rituximab; Hyaluronidase
- Sarilumab
- Tetanus Toxoid
- Tocilizumab
- Tofacitinib
- Triamcinolone
- Tuberculin Purified Protein Derivative, PPD
- Upadacitinib
- Vedolizumab
