Aclidinium Brand Name– TUDORZA PRESSAIR
What is Aclidinium
Aclidinium bromide is an inhaled long-acting muscarinic antagonist (LAMA).
It is given twice daily for the long-term maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema.
Statistically significant improvements in bronchodilation were demonstrated in all 3 placebo-controlled safety and efficacy trials.
According to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines, aclidinium may be used as initial monotherapy in all groups of COPD patients; however, combination therapy with a long-acting beta-agonist (LABA) or inhaled corticosteroid (ICS) may be needed in patients in Group D or in patients still experiencing dyspnea or exacerbations upon follow-up.
Aclidinium bromide is not indicated for acute bronchospasm and is not indicated for the treatment of asthma.
Aclidinium bromide was approved by the FDA in 2012
Indications
- chronic bronchitis
- chronic obstructive pulmonary disease (COPD)
- emphysema
For the maintenance treatment of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema
Side Effects
- anaphylactoid reactions
- angioedema
- AV block
- blurred vision
- bronchospasm
- cardiac arrest
- corneal edema
- cough
- dental pain
- diabetes mellitus
- diarrhea
- dysuria
- headache
- heart failure
- ocular hypertension
- ocular pain
- pharyngitis
- prostatic hypertrophy
- rash
- rhinitis
- sinusitis
- urethral pain
- urinary retention
- urticaria
- visual impairment
- vomiting
- xerostomia
Monitoring Parameters
- pulmonary function tests (PFTs)
Contraindications
- acute bronchospasm
- angioedema
- anticholinergic medications
- bladder obstruction
- breast-feeding
- children
- closed-angle glaucoma
- contact lenses
- geriatric
- infants
- milk protein hypersensitivity
- neonates
- ocular exposure
- ophthalmic administration
- pregnancy
- prostatic hypertrophy
Interactions
- Albuterol; Ipratropium
- Anticholinergics
- Atropine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benztropine
- Chlordiazepoxide; Clidinium
- Dicyclomine
- Flavoxate
- Fluticasone; Umeclidinium; Vilanterol
- Glycopyrrolate
- Glycopyrrolate; Formoterol
- Homatropine; Hydrocodone
- Hyoscyamine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Indacaterol; Glycopyrrolate
- Ipratropium
- Mepenzolate
- Methacholine
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methscopolamine
- Oxybutynin
- Propantheline
- Scopolamine
- Tiotropium
- Tiotropium; Olodaterol
- Trihexyphenidyl
- Umeclidinium
- Umeclidinium; Vilanterol
