What are the risks of radiation to the fetus? The risks associated with fetal radiation exposure depend on the gestational age of the fetus and the radiation dose absorbed [15] . During the first week after conception, there is an all-or-nothing effect for which the threshold radiation exposure is unknown in humans but ranges from 50 to …
Is intravascular gadolinium based contrast material contraindicated for use in pregnant women? Yes. Gadolinium-based contrast material is assumed to cross the blood-placental barrier and enter the fetus. Although there have been no known adverse effects to fetuses following maternal intravascular gadolinium-based contrast administration, no well-controlled studies of the teratogenic effects of gadolinium-based contrast material in …
Is intravascular iodinated contrast material contraindicated for use in pregnant women? No. Even though iodinated contrast material crosses the blood-placental barrier and enters the fetus, there have been no reports of neonatal hypothyroidism or teratogenic effects following maternal intravascular administration of iodinated contrast material. Because there are no available data to suggest any potential harm …
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Treatment for Pregnancy Associated APS Clinical Scenario Regimen Suggested Repeatedly positive aPLAs, but no history of pregnancy morbidity No treatment or consider low dose aspirinConsider prophylactic dose heparin for 6 weeks postpartum in patients with LAC and/or high-titer aPLAs due to risk of thrombosis High-risk repeatedly positive aPLAs + less than three consecutive pregnancy lossesTriple …
Physiologic Changes During Pregnancy Organ System Changes During Pregnancy Effects on a Patient with Autoimmune Disease Cardiovascular Increased plasma volumeIncreased heart rateIncreased stroke volumeVasodilation Can place strain on the heart if affected by CTDRaynaud’s phenomenon can improve Pulmonary Increased minute ventilationRespiratory alkalosis Can stress patients with underlying pulmonary disease such as ILDAvoid pregnancy in PHTN …
How do pregnancy outcomes vary among different types of vasculitis? • Antineutrophil cytoplasmic antibody-associated vasculitis: even if conception occurs with controlled disease, up to 40% of patients will flare during pregnancy. Disease activity during pregnancy is associated with preterm delivery and miscarriage as well as more serious outcomes. • Polyarteritis nodosa (PAN): conception during remission results in good outcomes …
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Should patients with a history of vasculitis get pregnant? There is limited data to guide management of pregnancy in vasculitis. Pregnancies are most likely to succeed when vasculitis is well controlled and patient is on low risk medications. These patients should be followed by obstetricians experienced with high-risk pregnancies and deliveries.