How useful is FDG PET for evaluation of peritoneal spread of tumor? FDG PET can detect peritoneal tumor implants, but the sensitivity is generally suboptimal given its low spatial resolution. In general, the smaller the lesion size, the greater the false-negative rate of FDG PET, although CT and MRI also have suboptimal sensitivity when peritoneal …
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What is the role of FDG PET in radiotherapy pretreatment planning? FDG PET plays an important role in radiotherapy pretreatment planning of cancer patients. It provides improved delineation of sites of malignancy, leading to treatment volume changes in up to 100% of patients and dose sparing of uninvolved tissues. In addition, FDG PET improves disease …
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What is the utility of FDG PET for disease staging and pretreatment planning of cancer patients? FDG PET improves the accuracy of tumor staging compared to CT alone and is currently utilized in the initial staging and pretreatment planning workup of patients with cancer. In particular, FDG PET improves N staging (for regional lymph nodes) …
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Is there a specific SUV threshold on FDG PET that can reliably distinguish malignant from benign disease processes? No, there is no one particular SUV threshold level that can reliably distinguish malignant from benign lesions on FDG PET. SUV measurements are affected by the scan acquisition parameters utilized, the delay time between FDG administration and …
What are the major causes for false positive FDG PET findings in cancer patients? False-positive FDG PET findings may occur when there is active infection or noninfectious inflammation of any cause. For example, bacterial infection, mycobacterial infection, and sarcoidosis can all lead to increased FDG uptake in the body, potentially mimicking malignancy. Iatrogenic inflammation following …
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What is the utility of FDG PET to characterize indeterminate lung nodules? Although chest CT is currently the mainstay for detecting lung nodules, lung nodules are often unable to be accurately characterized on CT alone as benign or malignant because structural imaging features are often nonspecific. FDG PET is useful to improve the characterization of …
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What are the major causes for false negative FDG PET findings in cancer patients? False-negative FDG PET findings may occur when there is low tumor metabolic activity, such as with lepidic-predominant adenocarcinomas (minimally invasive or in situ), mucinous adenocarcinomas, and carcinoid tumors, or when the lesions are small in size due to the limitations of …
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