Penbutolol Brand Name– Levatol What is Penbutolol Penbutolol is a nonselective beta-blocker and is available as an oral formulation indicated for hypertension. Due to its high lipid solubility, penbutolol undergoes extensive hepatic metabolism and has a higher potential for inducing CNS side effects relative to less lipid-soluble beta-blockers. Penbutolol has low intrinsic sympathomimetic activity (ISA) …
Pemoline Brand Name– Cylert What is Pemoline Pemoline is an oral central nervous system stimulant that is no longer available in the US because of liver toxicity. This agent possesses pharmacologic actions that are similar to those of the amphetamines and methylphenidate; however, its sympathomimetic effects are minimal. Because of its long half-life, pemoline can …
Pemirolast Brand Name– Alamast What is Pemirolast Pemirolast is a prescription ophthalmic product approved for relief of ophthalmic pruritis due to allergic conjunctivitis. Pemirolast is a mast cell stabilizer similar to cromolyn that inhibits the antigen-induced release of inflammatory mediators. Pemirolast is being investigated as a oral mast cell stabilizer, given twice daily for the …
Pemigatinib Brand Name– Pemazyre What is Pemigatinib Pemigatinib is an oral small molecule kinase inhibitor that targets fibroblast growth factor receptors (FGFR) 1, 2, and 3. It is indicated for the treatment of adults with previously treated, unresectable locally advanced or metastatic cholangiocarcinoma with an FGFR2 fusion or other rearrangement as detected by an FDA-approved …
Pemetrexed Brand Name– Alimta What is Pemetrexed Pemetrexed is a pyrimidine-based antifolate that suppresses tumor growth by inhibiting both DNA synthesis and folate metabolism at multiple target enzymes, including thymidine synthetase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT). The multiple enzyme inhibition is unique, as methotrexate inhibits only dihydrofolate reductase, and 5-fluorouracil and …
Pembrolizumab Brand Name– Keytruda What is Pembrolizumab Pembrolizumab is a programmed death receptor-1 (PD-1) blocking monoclonal antibody that works by preventing the interaction between PD-1 and the PD-L1 and PD-L2 ligands. It is indicated for the treatment of certain types of endometrial cancer, esophageal cancer, melanoma, non-small cell lung cancer (NSCLC), small cell lung cancer …
Pegvisomant Brand Names- Somavert | Somavert Kit What is Pegvisomant Pegvisomant is a growth hormone receptor antagonist, designed to block the effects of excessive growth hormone production by pituitary gland tumors. The drug is given subcutaneously and is used specifically for the treatment of acromegaly. Pegvisomant is an analog of human growth hormone that has been …