What medications are commonly associated with chronic tubulointerstitial nephritis? Analgesics, lithium, calcineurin inhibitors, Chinese herbs, chemotherapeutic agents, and heavy metals are associated with chronic tubulointerstitial nephritis.
What drugs cause Acute tubulointerstitial nephritis? The three most common drug classes that cause ATIN are: NSAIDs, proton-pump inhibitors, and antibiotics. Different drug classes are associated with different manifestations of ATIN. For example, while beta-lactam antibiotics may be associated with a systemic allergic response (fever, rash, and/or peripheral eosinophilia), NSAID-induced ATIN is not typically associated …
What drugs cause Acute tubulointerstitial nephritis Read More »
Is rituximab indicated in acquired TTP? Yes. Rituximab is an anti-CD20 monoclonal antibody. Its use in TTP is mainly indicated in adult TTP patients who are refractory to plasmapheresis and corticosteroids and in patients who have a relapsing course.
Side effects of nivolumab What side effects are associated with nivolumab (a PD-1 inhibitor) in RCC? The practitioner should be aware of potential autoimmune sequelae with novel checkpoint inhibitors. These include, for instance, autoimmune colitis, hepatitis, hypophysitis, thyroiditis, arthritis, and hepatitis. It is recommended that, in addition to surveillance for clinical manifestations of these symptoms, …
Side effects of everolimus and temsirolimus What side effects are associated with everolimus and temsirolimus? Class effects of the mTOR inhibitors include stomatitis, rash, fatigue, hyperglycemia, and hypertriglyceridemia. Pneumonitis (potentially severe) has also been noted with use of these agents
How is metastatic RCC treated What are the two classes of medications used to treat metastatic RCC? The two broad classes of agents used to treat metastatic RCC include (1) immunotherapy and (2) targeted therapy. Immunotherapy may be divided into the more classical cytokine-based treatments such as interferon-α (IFN-α) and high-dose interleukin-2 (IL-2), and novel …
Which drug is responsible for salt wasting? Cisplatin and ifosfamide directly injure the kidney tubular cells and impair the kidney sodium absorption and cause renal salt wasting.