How is Drug induced Lupus Erythematosus treated? The first and most important intervention is to discontinue the offending drug. Nonsteroidal antiinflammatory drugs will often help control the symptoms such as arthralgias, as the disease gradually resolves after the drug is stopped. Patients with more severe signs and symptoms, especially those with pericarditis or pleuritis, often …
Is the use of procainamide associated with DILE contraindicated in patients with SLE? Can they exacerbate disease activity? The population at risk for developing systemic DILE is very different compared with that developing idiopathic SLE. There is no evidence that drugs capable of causing systemic DILE will change or worsen disease activity in a patient …
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What drugs have been associated with causing drug induced SCLE? Hydrochlorothiazide, calcium channel blockers (e.g., diltiazem), angiotensin-converting enzyme inhibitors, proton pump inhibitors, terbinafine, anti-TNFα agents, statins, leflunomide, diclofenac, bupropion, and various agents to treat malignancies (e.g., docetaxel, hydroxyurea, anti-PD-L1 inhibitors, and others) are among the drugs that have been reported to cause SCLE. In addition …
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What drugs have been associated with causing chronic cutaneous Drug induced Lupus Erythematosus? Chronic cutaneous DILE presenting with discoid lesions is very rare. It is usually triggered by fluorouracil compounds or their modern derivatives such as capecitabine.
What are the Drugs for which there is more than anecdotal evidence for causing Drug induced Lupus Erythematosus Various drugs have been associated with causing DILE and can be categorized as follows: • Definite: procainamide, hydralazine, penicillamine, quinidine, isoniazid, minocycline, diltiazem (subacute cutaneous lupus rash), anti-TNFα agents, IFNα, methyldopa, chlorpromazine, and practolol. • Probable: anticonvulsants (mephenytoin, phenytoin, carbamazepine, others), …
What are the Drugs definitely associated with ANA production and manifestations of systemic Drug induced Lupus Erythematosus. What is the risk of developing DILE with each? High (>5%) Moderate Low (<1%) Procainamide (15%–20%) Quinidine Isoniazid Hydralazine (5%–10%) D-penicillamine Methyldopa Chlorpromazine Minocycline (5/10,000 patients) Anti-tumor necrosis factor α agents (2/1000 patients
What are the treatments for resistant causes of SCLE? • Stop smoking. May impair hydroxychloroquine effect • Hydroxychloroquine: may take 3 months to see the effect. Works best for tumid LE> SCLE> DLE. • Glucocorticoids: usually less than 30 mg/day • Belimumab: takes 4 to 6 months to help skin lesions. • Bullous lesions: dapsone (measure glucose-6-phosphate dehydrogenase level before …