Drugs

Role of long term antibiotics in enteric Reactive Arthritis Should long term antibiotics be used in enteric Reactive Arthritis? No. Antibiotic therapy for common postenteric-associated ReA has not been demonstrated in trials to reduce the severity of arthritis. The demonstration of bacterial cell wall antigens, but not nucleic acid in the synovial tissue, suggests that …

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Pharmacologic management of the extraarticular manifestations in Reactive Arthritis The mucocutaneous features of ReA are usually self-limited and may require no specific therapy. Topical corticosteroids and keratolytic agents may help keratoderma blennorrhagicum. Symptoms of uveitis should be referred for urgent ophthalmologic evaluation.

Role of long term antibiotics in Chlamydia related Reactive Arthritis Should long term antibiotics be used in Chlamydia related Reactive Arthritis? In chronic Chlamydia -related ReA, chlamydial organisms have been demonstrated in a metabolically active state in the synovial tissue; therefore, antibiotic therapy has been trialed. Results are mixed in randomized trials of long-term therapy with single antibiotics, …

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Pharmacologic management of the initial infection in Reactive Arthritis Elimination of the “triggering” infection with appropriate antibiotics is the first therapeutic goal in ReA. This is especially true for acute Chlamydia infections (azithromycin 1 g single dose or doxycycline 100 mg twice daily for 7 days, patient and partner). Patients with a history of Chlamydia- related ReA should be …

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What dose adjustments need to be made for antirheumatic medications in patients with severe hepatobiliary disease? Severe liver disease can be defined as a combination of one or more of the following factors: elevated bilirubin > 3 mg/dL, albumin < 3 g/dL with ascites, elevated prothrombin time/international normalized ratio not fully corrected by vitamin K, …

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How is Axial Spondyloarthritis treated Which medications are helpful in the management of axSpA? Although there is no cure for axSpA, most patients can be managed by controlling inflammatory symptoms and participating in an exercise program to minimize deformity and disability. The following modalities are helpful: NSAIDs. These may improve symptoms to a much greater degree …

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How is Relapsing Polychondritis treated What medications are used in the treatment of Relapsing Polychondritis? Nonsteroidal antiinflammatory drugs, dapsone, and low-dose prednisone may be used to control minor inflammatory episodes. However, with more active disease, prednisone doses of 20 to 60 mg/day may be required until control is attained. Methylprednisolone pulses (1 g/day × 3 …

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