Drug of choice for Pagets Disease of Bone Which pharmacological agent is the drug of choice for Pagets Disease of Bone? Zoledronate, an IV infusion, is the drug of choice for PDB because it has the fastest, most dramatic, and sustained effect on ALP and symptoms (pain, quality of life). After a single dose, 96% …
Osteoporosis medications for over age 40 years When should osteoporosis medications be instituted in patients over age 40 years who are on Glucocorticoids therapy? Which medications are effective? The decision to initiate a bone-active agent is based on risk stratification using the GC-adjusted WHO FRAX tool, lowest T-score value, and history of fragility fracture. Note , in patients …
How should patients on Glucocorticoids be monitored? Patients starting GC therapy (prednisone dose > 2.5–5 mg/day or equivalent) with a planned duration of treatment >3 months or on existing treatment for >3 months should have their BMD tested and FRAX score calculated at the start of therapy and preferably every 12 months as long as …
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How do Glucocorticoids cause osteoporosis? GCs adversely affect both phases of bone remodeling leading to rapid loss of bone. They impair bone formation by promoting apoptosis of existing osteoblasts and reducing the development of new osteoblasts. They increase bone resorption by decreasing the production of sex steroids and osteoprotegerin, an endogenous inhibitor of bone resorption. …
Latest treatment for Osteoarthritis What other therapies are being used or developed for Osteoarthritis? • Autologous chondrocyte implantation. Matrix-assisted autologous chondrocyte implantation has had promising results in initial clinical studies. More commonly utilized in younger patients with smaller cartilage defects. • Abrasion and microfracture surgery. Microdrilling of subchondral bone releases autologous mesenchymal stem cells from the bone marrow that …
How does viscosupplementation compare with NSAIDs or intraarticular corticosteroid injections? The role of viscosupplementation in knee OA is controversial. Some clinical trials suggest that pain relief is equivalent to NSAIDs without the gastrointestinal side effects. More recently, metaanalyses of double-blind controlled trials have shown no greater relief than placebo “sham” injections (of interest, other studies …
Are glucosamine and chondroitin effective in treating Osteoarthritis? The published studies show conflicting results . Glucosamine sulfate (or hydrochloride) and chondroitin sulfate (so-called nutraceuticals) are classified as dietary supplements and as such are not regulated by the Food and Drug Administration (FDA). Consequently, compound amount, purity, long-term safety, and product labeling are not guaranteed. Absorption of both …
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