What is Ropinirole Ropinirole is an oral non-ergot alkaloid dopamine agonist. It is indicated for the treatment of signs and symptoms associated with idiopathic Parkinson’s disease in adults, both as early monotherapy and in combination with levodopa. As with other dopamine agonists, the drug has also proven effective for treating restless leg syndrome (RLS) in …
What is Romosozumab Romosozumab is a parenteral humanized IgG2 monoclonal antibody and sclerostin inhibitor. Romosozumab (Evenity) is an anabolic agent that was FDA approved in 2019. It is a humanized monoclonal antibody directed against sclerostin, a protein produced by osteocytes that is a natural inhibitor of the Wnt pathway; Wnt is the major signaling cascade that …
What is Romiplostim Romiplostim is an injectable thrombopoietin receptor agonist produced by recombinant DNA technology in Escherichia coli. It is used for the treatment of thrombocytopenia in adult patients with chronic immune thrombocytopenia (ITP) who have had an insufficient response to corticosteroids, immunoglobins, or splenectomy; it may also be used in children and adolescents with ITP …
What is Romidepsin Romidepsin is a histone deacetylase (HDAC) inhibitor that is indicated for the treatment of cutaneous T-cell lymphoma and peripheral T-cell lymphoma in patients who have received at least 1 prior systemic treatment. Electrocardiogram abnormalities including QT interval prolongation have been reported; ensure potassium and magnesium levels are within normal range before administering …
What is Rolapitant Rolapitant is a substance P/neurokinin 1 (NK1) receptor antagonist that is used in adults in combination with dexamethasone and a 5-HT3 receptor antagonist for the prevention of chemotherapy-induced delayed nausea and vomiting. Rolapitant inhibits the CYP2D6 enzyme, Breast-Cancer-Resistant Protein (BCRP), and P-gp. Rolapitant is contraindicated with CYP2D6 substrates with a narrow therapeutic …
What is Roflumilast Roflumilast is a phosphodiesterase-4 (PDE4) inhibitor. The PDE4 enzyme is preferentially expressed in pro-inflammatory cells; inhibition results in intracellular accumulation of cyclic-AMP, a process which appears to down-regulate inflammation. The drug is used to reduce chronic obstructive pulmonary disease (COPD) exacerbations in adults with severe COPD associated with bronchitis and a history …
What is Rofecoxib Rofecoxib is a selective cyclooxygenase-2 (COX-2), nonsteroidal anti-inflammatory drug (NSAID). Compared to celecoxib, another COX-2 selective NSAID, rofecoxib lacks a sulfonamide chain and is not primarily dependent on cytochrome P-450 enzymes for metabolism. Rofecoxib demonstrates comparable efficacy to non-selective NSAIDs (e.g. ibuprofen and diclofenac) in patients with osteoarthritis or acute pain. In …