What is Rufinamide Rufinamide is a triazole derivative that is unrelated to currently marketed anticonvulsants. Although rufinamide is only FDA-approved for use in Lennox-Gastaut syndrome, clinical trial data indicate the drug may also be beneficial as adjunctive treatment of refractory partial seizures. Rufinamide was FDA-approved in November 2008 with an orphan drug designation for the …
What is Rucaparib Rucaparib is an oral poly (ADP-ribose) polymerase (PARP) inhibitor. It is indicated as monotherapy for the treatment of patients with BRCA-mutated ovarian cancer after 2 or more prior chemotherapy regimens, and for the maintenance treatment of recurrent ovarian cancer. It is also indicated for the treatment of BRCA-mutated metastatic castration-resistant prostate cancer, …
What is Rubidium Rb 82 Chloride Rubidium Rb 82 chloride is a radioactive diagnostic agent used for positron emission tomography (PET) imaging of the myocardium under rest or pharmacologic stress to evaluate regional myocardial perfusion in adults with suspected or known coronary artery disease. The physical half-life of Rb 82 is 75 seconds; therefore, the …
What is Rotigotine Rotigotine hydrochloride is a transdermal non-ergoline dopamine agonist used for the treatment of Parkinson’s disease (PD) and restless leg syndrome (RLS). Effectiveness with and without concomitant levodopa treatment was established in advanced and early stage PD patients, respectively. In one study, median oral doses of levodopa significantly decreased from 1400 mg/day to …
What is Rosuvastatin Rosuvastatin is a selective, competitive, HMG-CoA reductase inhibitor. It potently reduces total and LDL cholesterol and lowers plasma triglycerides and apolipoprotein B (Apo-B). Because of its chemical structure binding sites and relatively greater hydrophilicity, it appears to better penetrate the hepatocyte and bind to HMG-CoA reductase with a higher affinity than other …
What is Rosiglitazone Rosiglitazone is an oral antidiabetic agent and a member of the group of drugs known as thiazolidinediones (TZDs), also called ‘insulin sensitizers’. TZDs specifically target insulin resistance, which is thought to be central to the development of Type 2 diabetes mellitus (DM) as well as dyslipidemia and hypertension in patients with DM. …
What is Ropivacaine Ropivacaine is a long-acting, amide-type local anesthetic. Its structure and pharmacokinetics are similar to those of bupivacaine; however, ropivacaine appears to be less arrhythmogenic than bupivacaine. Ropivacaine is the S-isomer form, whereas bupivacaine is the R- isomer. In contrast to other local anesthetics, the systemic absorption of ropivacaine is not affected by …