What is Testosterone Testosterone is the primary androgen found in the body. Endogenous testosterone is synthesized by cells in the testes, ovaries, and the adrenal cortex. Therapeutically, testosterone is used in the management of primary or acquired hypogonadism in males (adolescent or adult), and use is also appropriate for selected adolescent males with constitutional delay …
What is Testolactone Although originally approved as a palliative treatment for disseminated or advanced breast cancer, testolactone was removed from the market by the manufacturer in February, 2008. Testolactone is a first generation, steroid aromatase inhibitor. Testolactone decreases serum estrogen concentrations. Originally classified as a weak androgen, it was not until 1975 that its potent …
What is Tesamorelin Tesamorelin is a synthetic growth hormone releasing factor (GRF) analog that is given subcutaneously. It is the first treatment indicated to reduce excess abdominal fat in HIV-infected patients with lipodystrophy. Treatment was well-tolerated during clinical trials with hypersensitivity and injection site reactions being the most commonly reported adverse events. Treatment is contraindicated …
What is Teriparatide Teriparatide is recombinant parathyroid hormone, identical to the 34 N-terminal amino acids of human parathyroid hormone (PTH). This amino terminal chain of PTH appears to be responsible for its chief biologic effects, including the regulation of calcium at the bone. In addition to reducing bone turnover as other treatments for osteoporosis do, …
What is Teriflunomide Teriflunomide is an oral pyrimidine synthesis inhibitor, and an active metabolite of leflunomide. Teriflunomide is indicated for the treatment of relapsing forms of multiple sclerosis, including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease. Teriflunomide inhibits dihydroorotate dehydrogenase, which is a mitochondrial enzyme involved in de novo pyrimidine synthesis. In clinical trials …
What is Terfenadine NOTE: This drug is discontinued in the U.S. Terfenadine was a non-sedating antihistamine (H1-blocker) that is similar in structure to astemizole. Terfenadine, however, had a much shorter duration of action. Both agents were structurally similar to haloperidol, a butyrophenone antipsychotic. Interestingly, all 3 agents have been associated with torsade de pointes (TdP). …
What is Terconazole Terconazole is a triazole antifungal agent available for intravaginal use. It is structurally related to imidazole-derivative antifungal agents, although imidazoles have 2 nitrogens in the azole ring while terconazole and other triazoles have 3 nitrogens in the azole ring. Terconazole is usually fungicidal against Candida albicans. Although antifungal activity has been demonstrated against …