What is Tocilizumab Tocilizumab is a humanized interleukin-6 (IL-6) receptor-inhibiting monoclonal antibody produced in mammalian (Chinese hamster ovary) cells. In patients with inflammatory diseases such as rheumatoid arthritis, IL-6 concentrations correlate with disease activity and joint or tissue damage. In adults, tocilizumab is FDA approved for the treatment of moderate to severe rheumatoid arthritis (RA) …
What is Tocainide NOTE: This drug is discontinued in the US. Tocainide is an oral, local anesthetic-type antiarrhythmic agent similar to both lidocaine and mexiletine. Tocainide is categorized as a class Ib antiarrhythmic according to the Vaughan-Williams classification of antiarrhythmic agents and is used in the treatment of ventricular arrhythmias including unifocal and multifocal ventricular …
What is Tobramycin Tobramycin is an aminoglycoside antibiotic obtained from cultures of Streptomyces tenebrarius. It is most active against aerobic gram-negative rods and, in combination with other antibiotics, is used to treat Staphylococcus aureus and certain species of Streptococcus. Tobramycin and some other aminoglycosides are used in combination with a penicillin for the treatment of endocarditis. Tobramycin also possesses …
What is Tizanidine Tizanidine is an oral agent used to reduce muscle tone associated with spasticity related to cerebral or spinal cord injury, multiple sclerosis, or other spastic disorders. The imidazoline chemical structure of tizanidine is related to that of clonidine and other central-acting alpha2-adrenergic agonists. Tizanidine significantly reduces muscle tone and frequency of spasms …
What is Tisagenlecleucel Tisagenlecleucel is a chimeric antigen receptor (CAR) T-cell therapy and the first gene therapy approved by the FDA. It is CD19-directed immunotherapy that works by using a patient’s own genetically altered immune cells to kill B-cell cancer cells in the blood. Tisagenlecleucel is indicated for use in patients up to 25 years …
What is Tirofiban Tirofiban is a synthetic non-peptide platelet glycoprotein IIb/IIIa inhibitor approved for rate reduction of thrombotic cardiovascular events in patients with non-ST elevation acute coronary syndromes. Inhibition of the platelet glycoprotein IIb/IIIa receptor prevents platelet aggregation. Tirofiban has a low molecular weight and little, if any, immunogenicity. When administered at the recommended dosage, …
What is Tipranavir Tipranavir is a non-peptidic protease inhibitor (PI), indicated for use in combination with ritonavir and other antiretroviral medications to treat HIV-1 infected patients who are treatment-experienced and infected with HIV-1 strains resistant to more than 1 PI. The non-peptidic structure theoretically exhibits greater flexibility in conforming to HIV protease variants that are …