What is Trabectedin Trabectedin is an alkylating agent indicated for the treatment of unresectable or metastatic liposarcoma and leiomyosarcoma in patients that had previously received anthracycline-containing chemotherapy. Neutropenic sepsis, hepatotoxicity, rhabdomyolysis, and cardiomyopathy have been reported with trabectedin use. Brand Name Yondelis Indications soft-tissue sarcoma Side Effects anemia anemia anorexia anorexia arthralgia asthenia capillary leak …
What is Tositumomab The tositumomab therapeutic regimen uses radioimmunotherapy in a 2-step approach that combines a radionuclide and monoclonal antibody for the treatment of non-Hodgkin’s lymphoma (NHL). Tositumomab is a murine IgG2a gamma monoclonal anti-CD20 antibody. The CD20 antigen (human B-lymphocyte-restricted differentiation antigen, Bp-35) is a hydrophobic transmembrane protein located on normal and malignant pre-B and …
What is Torsemide Torsemide is an oral and IV loop diuretic, the most active of a new series of anilinopyridine sulfonylurea derivatives. On a weight to weight basis torsemide is twice as potent as furosemide, and provides a longer duration of action at lower urinary concentrations. This allows for a 24-hour dosage interval and avoids …
What is Toremifene Toremifene is an oral nonsteroidal antiestrogen for the treatment of metastatic breast cancer in postmenopausal women. It is a derivative of tamoxifen, which is also an antiestrogen. Toremifene is as effective as tamoxifen in treating metastatic breast cancer; cross-resistance has been suggested. Toremifene may also have a more favorable effect on lipid …
What is Topotecan Topotecan is a semi-synthetic, water-soluble derivative of camptothecin, a cytotoxic plant alkaloid isolated from the Chinese tree Camptotheca acuminata. It is a topoisomerase I inhibitor that is FDA approved in capsule form as monotherapy for the treatment of small cell lung cancer (SCLC), and as an intravenous therapy for the treatment of ovarian …
What is Topiramate Topiramate is an oral antiepileptic drug (AED) used for partial-onset, generalized primary tonic-clonic seizures, and as an adjunct therapy in Lennox-Gastaut syndrome. It is derived from the naturally occurring monosaccharide D-fructose and is structurally different from other AEDs. Unlike other AEDs, topiramate appears to block the spread of seizures rather than raise …
What is Tolvaptan Tolvaptan is an oral selective vasopressin V2-receptor antagonist. One tolvaptan product, Samsca, is indicated for the treatment of clinically significant hypervolemic and euvolemic hyponatremia (i.e., serum sodium less than 125 mEq/L or less marked hyponatremia that is symptomatic and has resisted correction with fluid restriction), including in patients with heart failure and …