What is Valsartan Valsartan is a specific angiotensin II antagonist which selectively and competitively blocks the AT1 receptor, which mediates the vasopressor and aldosterone effects of angiotensin II. Unlike losartan, valsartan does not have an active metabolite or possess uricosuric effects. Valsartan is used to treatment hypertension in adults and children >= 6 years of age; …
What is Valrubicin Valrubicin is a semisynthetic analog of doxorubicin indicated for intravesical therapy of BCG-resistant carcinoma in situ (CIS) of the bladder in patients for whom immediate cystectomy would be associated with unacceptable morbidity or mortality. It has been shown to induce complete response in only about 1 in 5 patients with BCG-refractory CIS; …
What is Valproic Acid Divalproex Sodium Valproic acid and divalproex sodium are anticonvulsants that are chemically unrelated to other anticonvulsants. Valproic acid was synthesized over a century ago, but its anticonvulsant properties were not discovered until 1963. Sodium valproate is the sodium salt of valproic acid. Divalproex sodium contains sodium valproate and valproic acid in …
What is Valganciclovir Valganciclovir is the L-valyl ester of ganciclovir (i.e., a prodrug), which exists as a mixture of two diastereomers. After oral administration, both diastereomers are rapidly converted to ganciclovir. Ganciclovir is a synthetic analog of guanine and is effective against human cytomegalovirus (CMV) infections. The advantage of valganciclovir is the ability to attain in …
What is Valerian (Valeriana officinalis) Valerian is obtained from the dried rhizome and roots of the perennial herb Valeriana officinalis (family Valerianaceae). Valerian has a long history of use in Europe, including ancient Greece, for the treatment of various internal and external ailments. In the U.S., valerian was used as a tranquilizer through the time of World …
What is Valdecoxib NOTE: This drug is discontinued in the US. Valdecoxib is a selective cyclooxygenase-2 (COX-2), nonsteroidal anti-inflammatory drug (NSAID). Valdecoxib exhibits anti-inflammatory, analgesic, and antipyretic activities but does not inhibit platelet aggregation. It is indicated for the management of dysmenorrhea, osteoarthritis, and rheumatoid arthritis. Clinical trials have demonstrated similar efficacy and a significantly …
What is Valbenazine Valbenazine is an oral pre-synaptic human vesicular monoamine transporter type 2 (VMAT2) inhibitor. The drug causes an inhibition of dopamine release via this mechanism. It is used to treat tardive dyskinesia (TD). The efficacy of valbenazine in treating TD was shown in a randomized, double-blind, placebo controlled clinical trial (the KINECT 3 …