Nedosiran – Description Indications & Dosage For the treatment of primary hyperoxaluria type 1 Note: Nedosiran has been designated as an orphan drug for this indication by the FDA. Subcutaneous dosage Adults weighing 50 kg or more: 160 mg subcutaneously once monthly.69571 Adults weighing less than 50 kg: 128 mg subcutaneously once monthly.69571 Children and Adolescents …
Nadofaragene Firadenovec – Description Indications & Dosage For the treatment of bladder cancer For the treatment of high-risk Bacillus Calmette-Guerin (BCG)-unresponsive non-muscle invasive bladder cancer (NMIBC) with carcinoma in situ (CIS) with or without papillary tumors Precautions Pregnancy Lactation Interactions Adverse Reactions Administration Mechanism of Action Pharmacokinetics •Route-Specific Pharmacokinetics Other Route(s) Intravesical Administration Monitoring Parameters Classifications …
Oliceridine – Description Indications & Dosage Maximum Dosage Limits: •Adults 3 mg/dose IV and 27 mg/day IV. •Geriatric 3 mg/dose IV and 27 mg/day IV. •Adolescents Safety and efficacy have not been established. •Children Safety and efficacy have not been established. •Infants Safety and efficacy have not been established. •Neonates Safety and efficacy have not …
Olipudase Alfa – Description Indications & Dosage Maximum Dosage Limits: •Adults 3 mg/kg/dose IV every 2 weeks. •Geriatric 3 mg/kg/dose IV every 2 weeks. •Adolescents 3 mg/kg/dose IV every 2 weeks. •Children 3 mg/kg/dose IV every 2 weeks. •Infants 3 mg/kg/dose IV every 2 weeks. •Neonates 3 mg/kg/dose IV every 2 weeks. Patients with Hepatic …
Obecabtagene Autoleucel – Description Indications & Dosage Precautions Pregnancy Lactation It is not known if obecabtagene autoleucel is secreted in human milk or if it has effects on the breast-fed infant or on milk production. Consider the developmental and health benefits of breast-feeding along with the mother’s clinical need for obecabtagene autoleucel and any potential …
Lenacapavir – Description Indications & Dosage for initiation and maintenance dosing option 1 Oral dosage Adults: 600 mg PO plus subcutaneous lenacapavir on day 1, then 600 mg PO on day 2, followed by subcutaneous lenacapavir every 6 months.68383 Sucutaneous dosage Adults: 927 mg subcutaneously plus oral lenacapavir on Day 1, then oral lenacapavir on …
Ibrexafungerp (BREXAFEMME) – Description Indications & Dosage Contraindications Precautions Drug Interactions of Ibrexafungerp Adverse Reactions Mechanism of Action Ibrexafungerp is a triterpenoid antifungal agent and acts by inhibiting glucan synthase, an enzyme involved in the formation of beta (1,3)-D-glucan. Beta (1,3)-D-glucan is a major fungal cell wall component, and by disrupting its biosynthesis, ibrexafungerp compromises …