Depression

Core diagnostic features of Major Depressive Disorder

Core diagnostic features of Major Depressive Disorder What are the core diagnostic features for MDD? (Hint: the mnemonic SIG: E CAPS may help.)  There must be a pervasive and persistent depressive mood (or irritable mood in children and adolescents) and/or loss of interest/pleasure (anhedonia) for ≥2 weeks and ≥4 of the following symptoms (recalled with …

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Why antidepressants not for bipolar depression

Why should antidepressants not be used in isolation (without a mood stabilizer) for bipolar depression?  Unchecked, antidepressants may precipitate a manic episode in susceptible patients (i.e., patients with an underlying bipolar disorder). This is one reason close follow-up of patients starting an SSRI for a first depressive episode is important.

First line therapy Antidepressants

First line therapy Antidepressants What class of antidepressant is generally considered as the first line therapy?  The SSRIs, because they are generally effective (but not necessarily more effective than other options) and generally better tolerated than other options, are considered first-line therapy for a number of psychiatric disorders including major depressive disorder, affect disorders, anxiety …

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Indications for antidepressants

What are the major indications for antidepressants?  Under the label of “antidepressants” falls a broad range of medications with diverse mechanisms of action and clinical utility beyond simply the treatment of depression.  Here is the table which lists some of major indications for antidepressants. Possible Indications for Antidepressants Major depressive disorder and other unipolar depressive …

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