What's on this Page
Pathophysiology of delirium
What is the pathophysiology (neurotransmitter disturbance) of delirium and how does this generalization help guide empiric treatment while investigations are under way to uncover the underlying cause?
In general, the delirious state is relatively hyperdopaminergic and hypocholinergic .
Thus, dopamine-blocking antipsychotics (especially haloperidol, risperidone, olanzapine, and quetiapine), usually at low doses, are a well-established recommended intervention and procholinergic agents (especially physostigmine in anticholinergic-induced delirium) may be of use, though the evidence base is mixed.
This is in addition to other supportive measures.
Polypharmacy (especially with anticholinergics) is a common cause of delirium, and regimen simplification (especially removal of anticholinergics, opiates, and other sedatives) is a very important intervention.
If delirium is diagnosed, what other psychiatric disorders can be diagnosed?
None!
